Gene interactions and pathways from curated databases and text-mining

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CSF3 — IL4

Text-mined interactions from Literome

Sloand et al., Blood 2000 : We studied the effect of G-CSF on interferon (IFN)-gamma and IL-4 expression in CD4 ( + ) lymphocytes ... These results suggest that G-CSF decreases IFN-gamma and increases IL-4 production in vitro and in vivo and likely modulates a balance between TH1 and TH2 cells, an effect that may be important in PBSC transplantation
Nawa et al., Bone Marrow Transplant 2000 (Graft vs Host Disease) : G-CSF reduces IFN-gamma and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function
Hamilton et al., Immunology 1992 : Both IL-4 ( > or = 10 pM ) and the glucocorticoid, dexamethasone ( 10 ( -7 ) M ), inhibited G-CSF production in the LPS treated monocytes ; in contrast, IFN-gamma had a weak potentiating effect on the LPS action
Vellenga et al., Blood 1990 (Leukemia) : In the blast colony assay, IL-4 suppressed the IL-3 supported AML-CFU in the majority of cases, but enhanced the G-CSF stimulated AML-CFU in 3 of 6 cases
Akahane et al., Arzneimittelforschung 1990 : The enhanced G-CSF production from NFSA cells may be due at least to interleukin-1 released from muroctasin stimulated macrophages
Leizer et al., Blood 1990 : Cytokine regulation of colony stimulating factor production in cultured human synovial fibroblasts : I. Induction of GM-CSF and G-CSF production by interleukin-1 and tumor necrosis factor
Vellenga et al., Br J Haematol 1991 : IL-4 ( 15 ng/ml ) did not induce G-CSF transcripts in monocytes but suppressed the endotoxin induced G-CSF expression when added simultaneously ... Finally it was demonstrated that IL-4 had comparable effects on the G-CSF secretion of endotoxin and IL-1 stimulated human monocytes by using a murine bone marrow assay
Rodríguez-Cortés et al., J Clin Apher 2010 : Granulocyte colony stimulating factor produces a decrease in IFNgamma and increase in IL-4 when administrated to healthy donors
Jiang et al., J Int Med Res 2010 (Alzheimer Disease...) : Levels of a7 nAChR protein were significantly increased and levels of interleukin-1ß , tumour necrosis factor-a and nuclear factor-?B ( NF-?B ) protein were significantly decreased in the brain of APP transgenic mice in response to G-CSF
Wang et al., Int J Oncol 1995 : We report that all-trans retinoic acid ( tRA ) synergizes with LPS to enhance the production of granulocyte colony stimulating factor ( G-CSF ) in PMA treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA
Broxmeyer et al., J Immunol 1988 : Use of specific CSF antibodies suggested that rhu IL-4 was enhancing the release of G-CSF and CSF-1 from monocytes and the release of GM-CSF and possibly G-CSF from PHA stimulated T lymphocytes
Ferrajoli et al., Ann Hematol 1993 : Therefore, we tested the effect of IL-4 on G-CSF receptors and found that 6- or 24-h incubation of low-density marrow cells with 1.0 microgram/ml IL-4 resulted in up-regulation of G-CSF receptors
Corcione et al., J Immunol 1994 : Because these stimuli rescued a large fraction of GC cells ( up to 50 % ) from spontaneous apoptosis in vitro, the finding may suggest that prevention of apoptotic death resulted in an increased G-CSF production or that CD40 mab and/or IL-4 increased G-CSF gene expression in G-CSF producing GC B cells
de Wit et al., Exp Hematol 1993 : Finally, it was observed that the potentiating effects of IFN-gamma on LPS induced G-CSF secretion could be blocked by interleukin-4 (IL-4)
Ogawa et al., Am J Hematol 1996 : IL-2, IL-3, IL-4 , IL-5, and IL-6 were unable to induce G-CSF production ... However, IL-4 promoted G-CSF production after stimulation with IL-1
Tuyt et al., Eur Cytokine Netw 1995 (Leukemia, Myeloid, Acute) : In 2/12 cases IL-4 inhibited the spontaneous or IL-1 and G-CSF supported proliferation ... In contrast to IL-10, IL-4 also inhibited the spontaneous ( 3/5 ) and cytokine induced ( 5/5 ) secretion of G-CSF and GM-CSF ( 4/5 ) protein in the cases in which an enhancement of the 3H-TdR uptake was noticed
Corcione et al., Methods 1997 (Leukemia, Lymphocytic, Chronic, B-Cell...) : A CD40 monoclonal antibody ( mAb ), recombinant ( r ) IL4 , and the combination of the CD40 mAb and rIL4 all increased G-CSF production by GC B cells
Pajkrt et al., Blood 1997 (Endotoxemia) : In group 1, G-CSF significantly enhanced the release of tumor necrosis factor (TNF), interleukin-6 (IL-6), IL-8, IL-1 receptor antagonist (IL-1ra), and soluble TNF receptors
Lenhoff et al., Exp Hematol 1998 : IL-4 and IL-13 affect GM-CSF and G-CSF secretion to the same extent