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CSF3 — IL4
Text-mined interactions from Literome
Sloand et al., Blood 2000
:
We studied the
effect of
G-CSF on interferon (IFN)-gamma and
IL-4 expression in CD4 ( + ) lymphocytes ... These results suggest that
G-CSF decreases IFN-gamma and
increases IL-4 production in vitro and in vivo and likely modulates a balance between TH1 and TH2 cells, an effect that may be important in PBSC transplantation
Nawa et al., Bone Marrow Transplant 2000
(Graft vs Host Disease) :
G-CSF reduces IFN-gamma and
IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function
Hamilton et al., Immunology 1992
:
Both
IL-4 ( > or = 10 pM ) and the glucocorticoid, dexamethasone ( 10 ( -7 ) M ),
inhibited G-CSF production in the LPS treated monocytes ; in contrast, IFN-gamma had a weak potentiating effect on the LPS action
Vellenga et al., Blood 1990
(Leukemia) :
In the blast colony assay,
IL-4 suppressed the IL-3 supported AML-CFU in the majority of cases, but
enhanced the
G-CSF stimulated AML-CFU in 3 of 6 cases
Akahane et al., Arzneimittelforschung 1990
:
The enhanced
G-CSF production from NFSA cells may be
due at least to
interleukin-1 released from muroctasin stimulated macrophages
Leizer et al., Blood 1990
:
Cytokine regulation of colony stimulating factor production in cultured human synovial fibroblasts : I.
Induction of GM-CSF and
G-CSF production by
interleukin-1 and tumor necrosis factor
Vellenga et al., Br J Haematol 1991
:
IL-4 ( 15 ng/ml ) did not induce G-CSF transcripts in monocytes but
suppressed the endotoxin induced
G-CSF expression when added simultaneously ... Finally it was demonstrated that
IL-4 had comparable effects on the
G-CSF secretion of endotoxin and IL-1 stimulated human monocytes by using a murine bone marrow assay
Rodríguez-Cortés et al., J Clin Apher 2010
:
Granulocyte colony stimulating factor produces a decrease in IFNgamma and
increase in
IL-4 when administrated to healthy donors
Jiang et al., J Int Med Res 2010
(Alzheimer Disease...) :
Levels of a7 nAChR protein were significantly increased and levels of
interleukin-1ß , tumour necrosis factor-a and nuclear factor-?B ( NF-?B ) protein were significantly decreased in the brain of APP transgenic mice in
response to
G-CSF
Wang et al., Int J Oncol 1995
:
We report that all-trans retinoic acid ( tRA ) synergizes with LPS to
enhance the production of granulocyte colony stimulating factor (
G-CSF ) in PMA treated cells, whereas the production of granulocyte-macrophage CSF,
interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA
Broxmeyer et al., J Immunol 1988
:
Use of specific CSF antibodies suggested that rhu
IL-4 was
enhancing the release of G-CSF and CSF-1 from monocytes and the release of GM-CSF and possibly
G-CSF from PHA stimulated T lymphocytes
Ferrajoli et al., Ann Hematol 1993
:
Therefore, we tested the
effect of
IL-4 on
G-CSF receptors and found that 6- or 24-h incubation of low-density marrow cells with 1.0 microgram/ml IL-4 resulted in up-regulation of G-CSF receptors
Corcione et al., J Immunol 1994
:
Because these stimuli rescued a large fraction of GC cells ( up to 50 % ) from spontaneous apoptosis in vitro, the finding may suggest that prevention of apoptotic death resulted in an increased
G-CSF production or that CD40 mab and/or
IL-4 increased G-CSF gene expression in G-CSF producing GC B cells
de Wit et al., Exp Hematol 1993
:
Finally, it was observed that the potentiating effects of IFN-gamma on LPS induced
G-CSF secretion could be
blocked by
interleukin-4 (IL-4)
Ogawa et al., Am J Hematol 1996
:
IL-2, IL-3,
IL-4 , IL-5, and IL-6 were unable to
induce G-CSF production ... However,
IL-4 promoted
G-CSF production after stimulation with IL-1
Tuyt et al., Eur Cytokine Netw 1995
(Leukemia, Myeloid, Acute) :
In 2/12 cases
IL-4 inhibited the spontaneous or IL-1 and
G-CSF supported proliferation ... In contrast to IL-10,
IL-4 also
inhibited the spontaneous ( 3/5 ) and cytokine induced ( 5/5 ) secretion of
G-CSF and GM-CSF ( 4/5 ) protein in the cases in which an enhancement of the 3H-TdR uptake was noticed
Corcione et al., Methods 1997
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
A CD40 monoclonal antibody ( mAb ), recombinant ( r )
IL4 , and the combination of the CD40 mAb and rIL4 all
increased G-CSF production by GC B cells
Pajkrt et al., Blood 1997
(Endotoxemia) :
In group 1,
G-CSF significantly
enhanced the release of tumor necrosis factor (TNF),
interleukin-6 (IL-6), IL-8, IL-1 receptor antagonist (IL-1ra), and soluble TNF receptors
Lenhoff et al., Exp Hematol 1998
:
IL-4 and IL-13
affect GM-CSF and
G-CSF secretion to the same extent