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CTGF — SMN1
Text-mined interactions from Literome
Yang et al., Zhonghua Yi Xue Za Zhi 2004
(Fibrosis) :
When cells were stimulated for 12 hours, the levels of MMP-2 mRNA were increased significantly in 100 ng/ml CTGF group and 5 ng/ml TGF-beta(1) group compared with vechile respectively beta ( 1.72 ), 1.68 vs 1.29, ( P < 0.01 ), decreased significantly in CTGF plus TGF-beta(1) group compared with CTGF group and TGF-beta(1) group, respectively ( 0.67 vs 1.72, 1.68, P < 0.01 ). 100 ng/ml CTGF had no prominent effect on the expression of alpha-SMA in cells and FN in supernatant medium ( P > 0.05 ), whereas 5 ng/ml TGF-beta(1) significantly stimulated both the expression of alpha-SMA and FN ( P < 0.05 ), and
CTGF plus TGF-beta(1)
induced more
alpha-SMA and FN compared with TGF-beta(1) ( P < 0.05 )
Yang et al., FASEB J 2004
(MAP Kinase Signaling System) :
Inhibition of LRP signaling reduced
CTGF mediated synergistic induction of
alpha-SMA protein
Zhang et al., Zhonghua Yi Xue Za Zhi 2005
:
The
CTGF mRNA expression of the HKC cells transfected with CTGF ASODN that was stimulated by TGF-beta1 10 microg/L was significantly suppressed ( P < 0.01 ) and the
alpha-SMA mRNA expression induced by TGF-beta1 10 microg/L was significantly
inhibited by CTGF ASODN transfection ( P < 0.01 )
Wu et al., Am J Nephrol 2010
:
Pretreatment of HK-2 cells with LXA ( 4 ) inhibited the morphological fibroblast-like changes and
alpha-SMA expression
induced by
CTGF but not by transforming growth factor-beta(1) ( TGF-beta(1) )
Sonnylal et al., J Cell Sci 2013
(Focal Epithelial Hyperplasia...) :
Both adenoviral expression of
CTGF in epithelial cells and treatment with recombinant CTGF
induced EMT-like morphological changes and expression of
a-SMA