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CTLA4 — NFKB1

Text-mined interactions from Literome

Fraser et al., Eur J Immunol 1999 : CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells
Olsson et al., J Biol Chem 1999 : CTLA-4 ligation suppresses CD28 induced NF-kappaB and AP-1 activity in mouse T cell blasts
Harlin et al., Eur J Immunol 2002 : CTLA-4 engagement regulates NF-kappaB activation in vivo ... In vitro, ligation of CTLA-4 reduces TCR mediated activation of NF-kappaB , a transcription factor implicated in promoting T cell survival and cytokine production ... However, whether NF-kappaB inhibition downstream of CTLA-4 is necessary for down-regulation of T cell responses is not known
Bour-Jordan et al., Nat Immunol 2003 : CTLA-4 deficiency also affects the balance of the nuclear factors NFATc1 and NFATc2, and enhances activation of NF-kappaB