Maruyama et al., Invest Ophthalmol Vis Sci 2001
(Keratoconus) :
Cotransfection experiments indicated that the up- or downregulation of LAP, cathepsin B , and alpha 2-M observed in keratoconus affected corneas was not mediated by Sp1 Yan et al., Biol Chem 2003
(Glioma) :
We have previously isolated the human cathepsin B promoter and shown that Sp1 and Ets factors are involved in the regulation of cathepsin B expression
Szpaderska et al., Anticancer Res 2004
(Melanoma, Experimental...) :
Sp1 regulates cathepsin B transcription and invasiveness in murine B16 melanoma cells ... Sp1 can regulate the capacity of B16F1 cells to degrade a reconstituted extracellular matrix in part by regulating cathepsin B expression