◀ Back to IFNG

CTSK — IFNG

Text-mined interactions from Literome

Kamolmatyakul et al., J Dent Res 2001 (Bone Resorption) : To test the hypothesis, we investigated the effect of IFN-gamma on cathepsin K expression in the MOCP-5 and wild-type mouse bone marrow co-culture systems by Northern blot as well as osteoclast formation at different stages of differentiation ... Consequently, cathepsin K protein production is also reduced by IFN-gamma
Pang et al., Biochem Biophys Res Commun 2005 : We have examined the role of IFN-gamma in the regulation of CTSK expression in the murine monocytic RAW 264.7 cell line, which can be readily differentiated to bone resorbing osteoclasts upon RANKL treatment ... In RAW cells stably transfected with a CTSK promoter-luciferase plasmid containing the 1618 bp upstream of the transcription initiation site, IFN-gamma inhibits CTSK promoter activity and ablates its induction by RANKL ... In conclusion, IFN-gamma and RANKL differentially regulate cathepsin K , S, and L gene expression in pre-osteoclastic cells, and there appears to be significant cross talk between the signal transduction pathways mediating the responses to RANKL and IFN-gamma