Gene interactions and pathways from curated databases and text-mining

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CXCL8 — IKBKB

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CXCL8 → IKBKB (increases, CXCL8 Activity) Newton et al., J Pharmacol Exp Ther 2007*
    Evidence: In these studies, IBN and dominantnegative IKK2, but not dominant-negative IKK1 or an empty (null) virus, prevented the induction of NF-B DNA binding and the induction of NF-B-dependent transcription in A549 cells (Catley et al., 2005). This previous study documented a parallel inhibitory effect on the expression of ICAM-1, GMCSF, and IL-8. In the current investigation, we have reexamined the supernatants from this earlier study and now extend our observations to include IL-6 (Fig. 1)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *