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CYBB — NOX3
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes NADPH oxidase complex:
NADPH oxidase complex complex (CYBB-NOXA1-NCF1-NOX3-NCF4)
Takeya et al., J Biol Chem 2003, Cheng et al., J Biol Chem 2006, Volpp et al., Proc Natl Acad Sci U S A 1989*, Parkos et al., J Clin Invest 1987*, Leto et al., Proc Natl Acad Sci U S A 1994, Wientjes et al., Biochem J 1993*
Text-mined interactions from Literome
Biberstine-Kinkade et al., J Biol Chem 1999
:
Expression of
gp91(phox) mutants R89T, D95A, D95R, R96A, R96E, or K102T did not significantly
affect NADPH oxidase activity
Noack et al., Hum Genet 1999
(Granulomatous Disease, Chronic) :
CGD is
caused by defects in the phagocyte
NADPH oxidase , a multiprotein enzyme that reduces oxygen to superoxide, a precursor of microbicidal oxidants
Xiao et al., Am J Physiol Cell Physiol 2002
(Cardiomegaly...) :
We found that ARVM express
gp91(phox) , p22(phox), p67(phox), and p47(phox), four major components of NAD ( P ) H oxidase, and that alpha ( 1 ) -AR stimulated ERK1/2 activation was
blocked by four structurally unrelated inhibitors of
NAD ( P ) H oxidase [ diphenyleneiodonium, phenylarsine oxide, 4- ( 2-aminoethyl ) benzenesulfonyl fluoride, and cadmium ]
Teissier et al., Circ Res 2004
(Inflammation) :
The PPAR-alpha induced increase in ROS was attributable to the induction of
NADPH oxidase , because ( 1 ) preincubation with the NADPH oxidase inhibitor diphenyleneiodinium prevented the increase in ROS production ; ( 2 ) PPAR-alpha agonists increased production measured by superoxide dismutase-inhibitable cytochrome c reduction ; ( 3 ) PPAR-alpha agonists
induced mRNA levels of the NADPH oxidase subunits p47(phox), p67phox, and
gp91phox and membrane p47phox protein levels ; and ( 4 ) induction of ROS production was abolished in p47phox-/- and gp91phox-/- macrophages
Anrather et al., J Biol Chem 2006
:
NF-kappaB
regulates phagocytic
NADPH oxidase by inducing the expression of
gp91phox
Rosenzweig et al., J Clin Immunol 2008
(Granulomatous Disease, Chronic...) :
CGD is
caused by defects in the
NADPH oxidase , the enzyme complex responsible for generation of superoxide and other reactive oxygen species ( ROS ) in phagocytic cells
Luengo-Blanco et al., Blood 2008
(Ectodermal Dysplasia...) :
These studies show that NF-kappaB is necessary for
CYBB and NCF1 gene expression and
activation of the phagocyte
NADPH oxidase in this model system
Tian et al., Am J Physiol Regul Integr Comp Physiol 2008
(Disease Models, Animal...) :
By day 35 in the high-Na S rats, mRNA expression of renal cortical
gp91phox , p22phox, p47phox, and p67phox NADPH subunits in S rats increased markedly, and treatment of high-Na S rats with the NADPH oxidase inhibitor apocynin
resulted in significant decreases in mRNA expression of these
NADPH oxidase subunits
Zhou et al., Free Radic Biol Med 2012
:
Rotenone
activates phagocyte
NADPH oxidase by binding to its membrane subunit
gp91phox
Shatynski et al., Eur J Immunol 2012
(Bacterial Infections...) :
Absence of phagocyte
NADPH oxidase ( NOX2 ) activity
causes chronic granulomatous disease (CGD) , a primary immunodeficiency characterized by recurrent bacterial infections
Vets et al., Molecular therapy. Nucleic acids 2013
:
Nevertheless,
gp91(phox) expression was stable for at least 6 months after electroporation and
NADPH-oxidase activity was
restored to normal levels as determined by superoxide production
Jackson et al., J Exp Med 1995
(Abscess...) :
Chronic granulomatous disease (CGD) is
caused by a congenital defect in phagocyte reduced nicotinamide dinucleotide phosphate (
NADPH ) oxidase production of superoxide and related species
Porter et al., Blood 1994
(Granulomatous Disease, Chronic) :
Chronic granulomatous disease (CGD) results from defects in the phagocyte nicotinamide adenine dinucleotide phosphate (
NADPH ) oxidase , central to which is the membrane bound cytochrome b-245
Marshall et al., Am J Respir Cell Mol Biol 1996
(Anoxia) :
Together these observations demonstrate that the unique
cytochrome b-245 containing NADPH-oxidase is present in pulmonary artery smooth muscle and that an
NADPH-oxidase or NADH-oxidoreductase complex is
activated to release superoxide by hypoxic conditions
Német et al., Orv Hetil 1997
(Common Variable Immunodeficiency...) :
Dysfunction of
NADPH oxidase results in
chronic granulomatous disease (CGD) , a syndrome characterized by severe bacterial and fungal infections
Becker et al., Hum Gene Ther 1998
(Granulomatous Disease, Chronic) :
CGD is
caused by a functional defect in the phagocytic nicotinamide adenine dinucleotide phosphatase (
NADPH ) oxidase ( phox ) enzyme complex, leading to a lack of microbicidal metabolites