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CYP7A1 — TNF

Text-mined interactions from Literome

Gupta et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Tumor necrosis factor-alpha , a potent activator of JNK, also rapidly activated JNK and down-regulated CYP7A1 mRNA levels
De Fabiani et al., J Biol Chem 2001 : The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene ( CYP7A1 ) converge to hepatic nuclear factor-4 : a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors
Dulos et al., Arthritis Rheum 2005 (Arthritis, Rheumatoid) : Stimulation with TNFalpha increased CYP7B activity in all cell lines tested
Dulos et al., Arthritis Res Ther 2005 (Arthritis, Rheumatoid) : The aim of this study was to elucidate which signal transduction pathway is involved in the TNF-alpha mediated induction of Cyp7b activity in FLS ... SN50 and PSI prevented the TNF-alpha induced increase in Cyp7b activity, whereas the mitogen activated protein kinase inhibitors PD98059 and SB203580 had no effect
Dulos et al., Ann N Y Acad Sci 2006 (Arthritis) : Next, we studied which signal transduction pathway is involved in the TNF-alpha mediated induction of Cyp7b activity in human FLS
Li et al., J Lipid Res 2008 : Previous studies show that TGFbeta1, TNFalpha , and insulin inhibit cholesterol 7alpha-hydroxylase ( CYP7A1 ) gene transcription and bile acid synthesis in human hepatocytes ... In this study, we investigated insulin, TGFbeta1, and TNFalpha regulation of rat Cyp7a1 gene transcription ... Furthermore, TNFalpha and cJun attenuated TGFbeta1 stimulation of rat Cyp7a1