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DBF4 — MCM2

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: Complex of CDC7-DBF4 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7 (protein-protein, phosphorylation)
  
• Reactome Reaction: DBF4 → MCM2 (indirect_complex) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999
• Reactome Reaction: DBF4 → MCM2 (reaction) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999, Masai et al., J Biol Chem 2000
• WikiPathways Cell Cycle: CDC7/DBF4 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-MCM8-MCM9-MCM10 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: DBF4 — MCM2 (direct interaction, enzymatic study) Masai et al., J Biol Chem 2000
• IRef Biogrid Interaction: DBF4 — MCM2 (direct interaction, two hybrid) Kneissl et al., J Mol Biol 2003
• IRef Hprd Interaction: DBF4 — MCM2 (two hybrid) Kneissl et al., J Mol Biol 2003

Text-mined interactions from Literome

Stead et al., BMC genetics 2012 : Together these observations point to a role for DDK mediated phosphorylation of Mcm2 in the response to replicative stress, including some forms of DNA damage
Ramer et al., J Biol Chem 2013 : In contrast, combining these two mutations resulted in synthetic lethality, suggesting that Mcm2 and Mcm4 play overlapping roles in the association of DDK with MCM rings at replication origins