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ADCYAP1 — DBH

Text-mined interactions from Literome

Choi et al., Peptides 1999 : DBH up-regulation by PACAP was reduced by H-89 and not further increased by forskolin showing involvement of cAMP/PKA ... PACAP increased tyrosine hydroxylase and dopamine beta-hydroxylase activities, but slightly lowered phenylethanolamine N-methyltransferase activity, resulting in a preferential rise in norepinephrine over epinephrine
Isobe et al., Neuropeptides 1996 : The phosphodiesterase inhibitor 3- isobutyl-1-methylxanthine potentiated the induction of TH and DBH mRNAs by PACAP ... In protein kinase C-downregulated cells pretreated with PMA for 24 h, the stimulatory effect of PACAP on TH and DBH gene expression was diminished ... These results suggest that cAMP and protein kinase C mediate the PACAP induced TH and DBH gene expression ... Removal of extracellular Ca2+ with EGTA enhanced the PACAP induced increases in both cellular cAMP and mRNA levels of TH and DBH , suggesting that Ca2+ has an inhibitory effect on the induction of TH and DBH mRNAs ... In conclusion, the present study indicates that PACAP coordinately upregulates the gene expression of both TH and DBH by activating the cAMP and protein kinase C signaling pathways, leading to simulation of cate-cholamine synthesis, while Ca2+ negatively regulates TH and DBH gene expression in porcine adrenal medullary cells