Gene interactions and pathways from curated databases and text-mining

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CASP3 — DFFB

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

McCarty et al., Biochem Biophys Res Commun 1999 : The mechanism of caspase activation of DFF40 is the disruption of the synergistic binding activity of DFF45 domains to DFF40 after caspase recognition and cleavage of DFF45 in the context of a DFF45/40 complex
Moriya et al., FEBS Lett 2000 (Neuroblastoma) : Thus, NO results in neuronal apoptosis through the sequential loss of mitochondrial membrane potential, caspase activation , and degradation of inhibitor of caspase activated DNase (CAD) ( CAD activation )
Zhou et al., Proc Natl Acad Sci U S A 2001 : Apoptotic DNA fragmentation is mediated by a caspase activated DNA fragmentation factor (DFF)40
Zhang et al., Apoptosis 2001 : During apoptosis, activated caspase-3 cleaves DFF45 and activates DFF40 , a DNase that targets nucleosomal linker region and cleaves chromatin DNA into nucleosomal fragments
Luo et al., J Cereb Blood Flow Metab 2002 (Disease Models, Animal...) : These results suggest that caspase-3 dependent caspase activated deoxyribonuclease activity plays an important role in mediating DNA fragmentation after focal ischemia
Widłak et al., Acta biochimica Polonica 2000 : DFF40/CAD is activated by caspase-3 that cuts the nuclease 's inhibitor DFF45/ICAD
Nagase et al., Immunol Lett 2002 (Sick Building Syndrome) : These findings indicate that satratoxin G-induced apoptosis involves activation of caspase-3 and DFF-40/CAD through both activation of caspase-8 and cytosolic accumulation of cytochrome c along with activation of caspase-9
Rao et al., Biochem Pharmacol 2005 : Ricin induced caspase-3 activation also resulted in cleavage of DNA fragmentation factor-45 ( DFF45/ICAD ) and DFF40 or caspase activated DNase in HeLa cells
Qi et al., Oncol Rep 2007 (Leukemia, Promyelocytic, Acute) : GP7 induced the release of cytochrome-c from mitochondria, activations of caspase-3 , -8, and -9, cleavage of DFF45/inhibitor of caspase activated DNase , activation of DFF40/caspase activated DNase, and apoptotic DNA fragmentation in NB4 cells
Dieker et al., Traffic 2012 : The dissociation requires caspase activity and involves caspase activated DNase (CAD)
Inohara et al., J Biol Chem 1999 : Deletion of the catalytic domain ( residues 290-345 ) abrogated the caspase-3 induced nuclease activity of DFF40/CAD but not its ability to interact with DFF45/ICAD