Gene interactions and pathways from curated databases and text-mining

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CAPN8 — DIABLO

Text-mined interactions from Literome

Das et al., Cancer 2007 (Glioblastoma) : Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and activation of calpain , caspase-9, and caspase-3
Das et al., J Neurooncol 2008 (Brain Neoplasms...) : The events of apoptosis included increase in expression of Bax, down regulation of Bcl-2 and baculoviral inhibitor-of-apoptosis protein (IAP) repeat containing ( BIRC ) proteins, mitochondrial release of cytochrome c and Smac into the cytosol, increase in intracellular free [ Ca ( 2+ ) ], and activation of calpain , caspase-9, and caspase-3
Das et al., Brain Res 2008 (Brain Neoplasms...) : Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac , downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules, an increase in intracellular free [Ca2+ ], and activation of calpain and caspase-3
Nijboer et al., Brain Behav Immun 2010 (Hypoxia-Ischemia, Brain) : We propose that inhibition of mitochondrial Smac/DIABLO release and calpain activation contribute to neuroprotection by TAT-JBD
Das et al., Cancer 2010 (Brain Neoplasms...) : Other events in apoptosis included overexpression of Bax, loss of DeltaPsi ( m ), mitochondrial release of cytochrome c and Smac into the cytosol, down-regulation of baculoviral inhibitor-of-apoptosis repeat containing proteins, and activation of calpain , caspase-9, and caspase-3