◀ Back to TNF

DUSP1 — TNF

Text-mined interactions from Literome

Rumora et al., Neurochem Int 2001 (Ovarian Neoplasms) : In contrast, TNF-alpha induces MKP-1 expression in PC12 cells and does not alter MKP-1 expression in HeLa cells ... Both bpV ( phen ) and TNF-alpha induce MKP-1 expression in OVCAR-3 cell line but with different dynamics : TNF-alpha causes transient and bpV ( phen ) sustained induction of MKP-1 expression
Chen et al., J Immunol 2002 : Ectopic expression of MKP-1 accelerated JNK and p38 inactivation and substantially inhibited the production of TNF-alpha and IL-6
Zhao et al., J Biol Chem 2005 (Inflammation...) : Adenovirus mediated MKP-1 overexpression significantly attenuated tumor necrosis factor alpha production in immortalized alveolar macrophages
Nimah et al., Shock 2005 : We hypothesized that MKP-1 expression induced during tolerance regulates TNF-alpha expression by inhibiting p38 activity
Tachado et al., Am J Respir Cell Mol Biol 2005 (HIV Infections...) : HIV nef protein was sufficient to reduce TNF-alpha release and induce MKP-1 in healthy macrophages ... Furthermore, targeted gene silencing of MKP-1 partially restored lipid A-mediated TNF-alpha release in HIV+ U1 cells
Bauer et al., J Cell Biochem 2007 (Carcinoma, Hepatocellular...) : Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA induced TNFalpha expression
Tephly et al., Am J Respir Cell Mol Biol 2007 : Since kinase activity is tightly regulated by phosphatases, we hypothesized that the dual specificity phosphatase MAP kinase phosphatase (MKP)-1 regulates p38 activity and TNF-alpha production in alveolar macrophages due to insufficient H ( 2 ) O ( 2 ) generation in response to asbestos
Kang et al., Am J Physiol Lung Cell Mol Physiol 2008 (MAP Kinase Signaling System) : In HASM cells, dexamethasone and TNF-alpha induced MKP-1 expression ( both mRNA and protein ) rapidly
Ajakaiye et al., Biochem Biophys Res Commun 2011 (Liver Diseases, Alcoholic) : Alcohol induced downregulation of MKP-1 leads to further release of TNF-a and hepatic injury
Yu et al., Cytokine 2011 : In the current study, MKP-1 specifically dephosphorylated activated MAPK responses and attenuated LPS induced IL-6, IL-10, and TNF-a expression
Zhang et al., Cardiovasc Res 2012 (Endotoxemia...) : MKP1 attenuates ERK1/2 and p38 activation, inhibits myocardial TNF-a expression, and improves cardiac function in endotoxemia
Guo et al., Am J Physiol 1999 : Although originally characterized as a PKC inhibitor, Ro-318220 inhibited TNF-alpha induced MKP-1 expression through a mechanism other than blocking the PKC pathway ... Furthermore, inhibition of the PKC pathway neither significantly affected TNF-alpha induced MKP-1 expression nor made cells susceptible to toxic effect of TNF-alpha