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EGFR — IL13
Text-mined interactions from Literome
Allahverdian et al., Am J Respir Cell Mol Biol 2008
:
Moreover, exogenous
IL-13 enhanced epithelial repair and induced
epidermal growth factor receptor (EGFR) phosphorylation ...
IL-13 induced
EGFR phosphorylation and the IL-13-reparative effect on AEC are mediated via HB-EGF ... Finally, we demonstrated that inhibition of
EGFR tyrosine kinase activity by tyrphostin AG1478
increases IL-13 release after injury, suggesting negative feedback between EGFR and IL-13 during repair
Lowry et al., Am J Respir Cell Mol Biol 2008
(Asthma...) :
In contrast,
IL-13 induced airway epithelial cell mucous cell hyperplasia, mucin and mucin related gene expression, epidermal growth factor receptor mRNA, and
epidermal growth factor receptor activation along with airway hyperreactivity in WT mice but not in GGT ( enu1 ) mice
Wu et al., J Neurosurg 2010
(Brain Injuries...) :
Simvastatin modified the caveolin-1 expression in lipid rafts in astrocyte cell membrane, suppressed the phosphorylation of
EGFR in lipid rafts of astrocytes after OGD, and
inhibited the OGD induced
interleukin-1 production