Gene interactions and pathways from curated databases and text-mining

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EIF2S1 — HSPA5

Text-mined interactions from Literome

Minakshi et al., PloS one 2009 : Only the PERK pathway was found to be activated in 3a-expressing cells based on ( 1 ) increased phosphorylation of eukaryotic initiation factor 2 alpha ( eIF2alpha ) and inhibitory effects of a dominant negative form of eIF2alpha on GRP78 promoter activity, ( 2 ) increased translation of activating transcription factor 4 (ATF4) mRNA, and ( 3 ) ATF4 dependent activation of the C/EBP homologous protein (CHOP) gene promoter
Brostrom et al., J Biol Chem 1995 : eIF-2 alpha phosphorylation and grp78 mRNA induction were measured in GH3 pituitary cells subjected to varied degrees of ER stress to ascertain whether activation of an eIF-2 alpha kinase is involved in both events