◀ Back to EIF4G1

EIF4A2 — EIF4G1

Pathways - manually collected, often from reviews:

• BioCarta eukaryotic protein translation: 40s Ribosome subunit/RNA strand complex () → 48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E) (modification, collaborate)
  
• BioCarta eukaryotic protein translation: eIF3 (EIF3S10) → 48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E) (modification, collaborate)
  
• BioCarta eukaryotic protein translation: eIF1 (EIF1) → 48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E) (modification, activates)
  
• BioCarta eukaryotic protein translation: 48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E) → EIF-2 complex (EIF2S1-EIF2S2-EIF2S3) (modification, collaborate)
  
• BioCarta eukaryotic protein translation: 43s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3) → 48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E) (modification, collaborate)
  
• BioCarta eukaryotic protein translation: 43s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3) → eIF4F/mRNA complex (EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E) (modification, collaborate)
  
• BioCarta eukaryotic protein translation: 48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E) → eIF4F/mRNA complex (EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E) (modification, collaborate)
  
• KEGG RNA transport: EIF4G1/EIF4G2/EIF4G3 → EIF4A1/EIF4A2 (protein-protein, binding/association)
• Reactome Reaction: EIF4A2 → EIF4G1 (reaction) Albert et al., Nucleic Acids Res 2000, Pestova et al., Nature 2000, Gao et al., Mol Cell 2000, Asano et al., Genes Dev 2000, Wilusz et al., Nat Rev Mol Cell Biol 2001, Chen et al., EMBO J 2002, Aström et al., J Biol Chem 1992, Parker et al., Nature structural & molecular biology 2004, Fritz et al., Cell Biochem Biophys 2004, Moore et al., Science 2005, Yamashita et al., Nature structural & molecular biology 2005, Kim et al., Mol Cell 2006, Garneau et al., Nat Rev Mol Cell Biol 2007, Chakrabarti et al., J Biol Chem 1991, Zheng et al., J Cell Biol 2008, Houseley et al., Cell 2009, Lau et al., Biochem J 2009, Peterson et al., J Biol Chem 1979, Trachsel et al., J Mol Biol 1977, Benne et al., J Biol Chem 1978, Yoder-Hill et al., J Biol Chem 1993*, Körner et al., J Biol Chem 1997
• Reactome Reaction: EIF4A2 → EIF4G1 (direct_complex) Wilusz et al., Nat Rev Mol Cell Biol 2001, Uchida et al., J Biol Chem 2004, Parker et al., Nature structural & molecular biology 2004, Fritz et al., Cell Biochem Biophys 2004, Moore et al., Science 2005, Yamashita et al., Nature structural & molecular biology 2005, Garneau et al., Nat Rev Mol Cell Biol 2007, Okumura et al., Genes Dev 2007, Siddiqui et al., J Biol Chem 2007, Zheng et al., J Cell Biol 2008, Houseley et al., Cell 2009
• Reactome Reaction: EIF4A2 → EIF4G1 (indirect_complex) Yoder-Hill et al., J Biol Chem 1993*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EIF4A2 — EIF4G1 (physical association, affinity chromatography technology) Ewing et al., Molecular systems biology 2007
• IRef Hprd Interaction: EIF4A2 — EIF4G1 (in vitro) Li et al., J Biol Chem 2001*
• IRef Intact Interaction: EIF4G1 — EIF4A2 (physical association, pull down) Li et al., J Biol Chem 2001*
• IRef Intact Interaction: EIF4G1 — EIF4A2 (physical association, coimmunoprecipitation) Li et al., J Biol Chem 2001*
• IRef Intact Interaction: EIF4G1 — EIF4A2 (physical association, anti bait coimmunoprecipitation) Ewing et al., Molecular systems biology 2007
• IRef Intact Interaction: Complex of 18 proteins (physical association, tandem affinity purification) Hutchins et al., Science 2010
• IRef Ophid Interaction: EIF4G1 — EIF4A2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: EIF4G1 — EIF4A2 (aggregation, confirmational text mining) Li et al., J Biol Chem 2001*