Gene interactions and pathways from curated databases and text-mining

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ESR1 — GNRH1

Text-mined interactions from Literome

Chen et al., Mol Cell Endocrinol 1999 : Estrogen receptor mediated repression of gonadotropin releasing hormone ( gnRH ) promoter activity in transfected CHO-K1 cells ... Results of this study demonstrated that estrogen receptor can mediate the negative feedback regulation of human GnRH upstream promoter activity by both estrogen and GnRH in the ovary
Chiang et al., J Clin Endocrinol Metab 2000 : Furthermore, our data suggest that the effects of hCG and GnRH on ERalpha and ERbeta expression in hGLCs are mediated in part by activation of PKA and PKC signaling pathways, respectively
Demay et al., Endocrinology 2001 : Moreover, we show that the effects of GnRH on ERalpha transcriptional activity in gonadotrope cell lines are mediated by the PKC/MAPK pathway
Hu et al., Mol Endocrinol 2008 : These findings demonstrate that the dual actions of E ( 2 ) on GnRH neuronal membrane excitability, cAMP production, and GnRH secretion are mediated by the dose dependent activation of ERalpha and ERbeta expressed in hypothalamic GnRH neurons
Chen et al., Endocrinology 2009 : These data demonstrate that GnRH mediated phosphorylation of ERalpha in mouse LbetaT2 pituitary cells results in its rapid association with PCAF and the transcriptional activation of fosB, and we demonstrate that this in turn likely activates other genes in pituitary cells including the FSH beta-subunit gene
Davis et al., Biol Reprod 2011 : The ability of E2 and E2-BSA to increase GnRH analog binding was blocked by the estrogen receptor ( ER ) antagonist ICI 182,780
Dong et al., Mol Cell Endocrinol 1996 : Evidence for estrogen receptor mediated regulation of human gonadotropin releasing hormone promoter activity in human placental cells