Saika et al., Endocrinology 2001
:
The stimulatory action of 17beta-E ( 2 ) on OPG expression appeared to be mediated by the estrogen receptor-alpha (ERalpha) subtype because stable overexpression of ERalpha , but not of ERbeta, enhanced the OPG induction by 17beta-E ( 2 )
Hofbauer et al., J Musculoskelet Neuronal Interact 2004
(Bone Diseases, Metabolic) :
Skeletal estrogen agonists ( including 17beta-estradiol, raloxifene, and genistein ) induce osteoblastic OPG production through estrogen receptor-alpha activation in vitro, while immune cells appear to over-express RANKL in estrogen deficiency in vivo