Gene interactions and pathways from curated databases and text-mining

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F2RL1 — IL1B

Text-mined interactions from Literome

Ritchie et al., Br J Pharmacol 2007 (Calcium Signaling...) : We investigated the effects of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) , trypsin and the PAR2 activating peptide, 2-furoyl ( 2f ) -LIGKV-OH on both mRNA and functional expression of PAR2 in human umbilical vein endothelial cells ( HUVECs )
Amiable et al., Bone 2009 (Bone Resorption...) : On OA osteoblasts, PAR-2 production was significantly increased by IL-1 beta , TNF-alpha and PGE ( 2 )
Tsai et al., J Biomed Sci 2009 (Disease Progression...) : TGF-beta inhibits IL-1beta activated PAR-2 expression through multiple pathways in human primary synovial cells ... It was demonstrated that IL-1beta induces PAR-2 expression via p38 pathway in hPSCs ... Because IL-1beta induced PAR-2 expressed in hPSCs might play a significantly important role in early phase of OA, PAR-2 repression by exogenous TGF-beta or other agents might be an ideal therapeutic target to prevent OA from progression