◀ Back to IL1B
F2RL1 — IL1B
Text-mined interactions from Literome
Ritchie et al., Br J Pharmacol 2007
(Calcium Signaling...) :
We investigated the
effects of tumour necrosis factor-alpha (TNF-alpha),
interleukin-1beta (IL-1beta) , trypsin and the PAR2 activating peptide, 2-furoyl ( 2f ) -LIGKV-OH on both mRNA and functional expression of
PAR2 in human umbilical vein endothelial cells ( HUVECs )
Amiable et al., Bone 2009
(Bone Resorption...) :
On OA osteoblasts,
PAR-2 production was significantly
increased by
IL-1 beta , TNF-alpha and PGE ( 2 )
Tsai et al., J Biomed Sci 2009
(Disease Progression...) :
TGF-beta inhibits
IL-1beta activated
PAR-2 expression through multiple pathways in human primary synovial cells ... It was demonstrated that
IL-1beta induces
PAR-2 expression via p38 pathway in hPSCs ... Because
IL-1beta induced
PAR-2 expressed in hPSCs might play a significantly important role in early phase of OA, PAR-2 repression by exogenous TGF-beta or other agents might be an ideal therapeutic target to prevent OA from progression