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FASLG — PIK3R1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Phu et al., J Leukoc Biol 2001
:
PI3-K inhibition during CTL induction
resulted in decreased levels of mRNAs coding for granzyme B, perforin, and
Fas ligand
Pardo et al., Int Immunol 2003
:
Altogether, the results suggest that TCR/CD3 induced
FasL gene transcription is
controlled by
PI3K and PKCtheta activation, while this signaling pathway is not implicated in CTL degranulation, which is rather dependent on the activation of classical PKC isoforms
Zhang et al., Front Biosci (Elite Ed) 2011
:
Taken together, the present study demonstrates that T3 potentiates the cell survival action of FSH through Src- and
PI3K mediated Xiap up-regulation and decreased Fas and
FasL expression