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FASLG — PIK3R1

Pathways - manually collected, often from reviews:

• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK) → PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1) (modification, activates)
  Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: FASLG — PIK3R1 (in vivo) Wenzel et al., FEBS Lett 2001
• IRef Intact Interaction: FASLG — PIK3R1 (direct interaction, phage display) Voss et al., BMC immunology 2009
• IRef Ophid Interaction: FASLG — PIK3R1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: FASLG — PIK3R1 (aggregation, confirmational text mining) Wenzel et al., FEBS Lett 2001

Text-mined interactions from Literome

Phu et al., J Leukoc Biol 2001 : PI3-K inhibition during CTL induction resulted in decreased levels of mRNAs coding for granzyme B, perforin, and Fas ligand
Pardo et al., Int Immunol 2003 : Altogether, the results suggest that TCR/CD3 induced FasL gene transcription is controlled by PI3K and PKCtheta activation, while this signaling pathway is not implicated in CTL degranulation, which is rather dependent on the activation of classical PKC isoforms
Zhang et al., Front Biosci (Elite Ed) 2011 : Taken together, the present study demonstrates that T3 potentiates the cell survival action of FSH through Src- and PI3K mediated Xiap up-regulation and decreased Fas and FasL expression