◀ Back to APOB

APOB — FCGR1A

Text-mined interactions from Literome

Bigler et al., Proc Natl Acad Sci U S A 1990 : Optimal expression of the high-affinity Fc receptor for IgG (FcRI) by the human monocyte cell line U-937 requires the presence of low density lipoprotein (LDL) , and neither cholesterol nor high density lipoprotein can provide the component necessary for optimal FcRI expression ... Thus, LDL is required for the expression of FcRI and FcR mediated phagocytosis by U-937 cells and may be an important regulator of phagocytic activity of monocytes and macrophages in vivo
Bigler et al., Biochim Biophys Acta 1989 : These studies indicate a role for LDL in regulating the expression of Fc gamma RI on the cell surface
Morganelli et al., J Lipid Res 1995 : Relative to appropriate controls, LDL degradation, cellular sterol mass, and foam cell development of monocytes were enhanced by targeting LDL aggregates to Fc gamma RI or Fc gamma RII, and this was accompanied by an apparent impairment of LDL degradation
Lopes-Virella et al., Atherosclerosis 1997 : Blocking experiments with aggregate-free IgG1 and CD32 monoclonal antibody confirmed that blocking Fc gamma RI prevented both LDL-IC uptake and the upregulation of LDL receptors on THP-1 cells