Gene interactions and pathways from curated databases and text-mining

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FGF18 — FGFR2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wang et al., Growth Factors 2000 : The biological activities of fibroblast growth factors ( FGF ) are mediated by specific cell membrane receptors ( FGFR ), which have three immunoglobulin-like IgG domains in the extracellular region
Morriss-Kay et al., Novartis Found Symp 2001 (Craniosynostoses) : Experimental increase of sutural FGF levels leads to down-regulation of Fgfr2 , up-regulation of Fgfr1, up-regulation of the osteogenic differentiation gene Osteopontin, and cessation of proliferation
Pellegrini et al., Curr Opin Struct Biol 2001 : Fibroblast growth factors ( FGFs ) are among the best studied heparin binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR
Kubota et al., Bone 2002 : On day 10, FGF-4 was not detected , whereas the expression of FGFR-1 and FGFR-2 was detectable in the area of alkaline phosphatase (ALP) expression
Anderson et al., J Neurochem 2005 : Dendrimeric FRM peptide was 125-fold more active and stimulated FGFR activation, FGFR dependent and FGF-mimetic neurite outgrowth and cell survival ( but not proliferation )
Buratini et al., Biol Reprod 2007 : Whereas many FGFs activate several FGF receptors, FGF7 and FGF10 primarily activate only one, FGFR2B ... Whereas many FGFs activate several FGF receptors, FGF7 and FGF10 primarily activate only one, FGFR2B
Zhao et al., Clin Cancer Res 2010 (Carcinoma...) : The capability of the mAbs to inhibit FGF induced FGFR2 phosphorylation and to downmodulate FGFR2 expression was also investigated
Li et al., Mol Cell Endocrinol 2012 : In hepatocyte, FGF-21 up-regulation reduced HMGR and PEPCK mRNA expression and increased ß-klotho, FGFR4 and LDLr expression ( p < 0.05 ), whereas down-regulation had the opposite effects
Ahmad et al., Biochim Biophys Acta 2012 (Cell Transformation, Neoplastic...) : FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy
Itoh et al., Development 1996 : These results suggest that the FGFR mediated FGF signaling ( 1 ) blocks terminal differentiation of myogenic cells within the somite and ( 2 ) sustains myoblast migration to limb buds from the somite, and that ( 3 ) down-regulation of FGFRs or FGFR signaling is involved in mechanisms triggering terminal differentiation of the limb muscle mass during avian embryogenesis
McKeehan et al., Prog Nucleic Acid Res Mol Biol 1998 : Divalent cations cooperate with the FGFRHS to conformationally restrict FGFRTK trans-phosphorylation, which causes depression of kinase activity and facilitates appropriate activation of the FGFR complex by FGF