◀ Back to FGF18
FGF18 — FGFR2
Pathways - manually collected, often from reviews:
-
KEGG MAPK signaling pathway:
FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9
→
FGFR1/FGFR2/FGFR3/FGFR4
(protein-protein, activation)
-
KEGG Pathways in cancer:
FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9
→
FGFR1/FGFR2/FGFR3
(protein-protein, activation)
-
Reactome Reaction:
FGF18
→
FGFR2
(reaction)
Carpenter et al., Exp Cell Res 1999, Stauber et al., Proc Natl Acad Sci U S A 2000, Yu et al., Proc Natl Acad Sci U S A 2000, Hart et al., Mol Biol Cell 2001, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Mohammadi et al., Nature 1992, Agazie et al., Oncogene 2003, Ibrahimi et al., Hum Mol Genet 2004, Mohammadi et al., Mol Cell Biol 1991, Dionne et al., EMBO J 1990, Takeda et al., Clin Cancer Res 2007, Pollock et al., Oncogene 2007, Ahmed et al., Biochem J 2008, Dutt et al., Proc Natl Acad Sci U S A 2008, Byron et al., Cancer Res 2008, Schüller et al., Biochem J 2008, Qing et al., J Clin Invest 2009, Turner et al., Nat Rev Cancer 2010, Byron et al., Gynecol Oncol 2010, Bai et al., Cancer Res 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Wilkie et al., Nat Genet 1995, Wang et al., Mol Cell Biol 1994, Mohammadi et al., Mol Cell Biol 1996, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Lomri et al., J Clin Invest 1998, Hadari et al., Mol Cell Biol 1998, Raffioni et al., J Biol Chem 1998
-
Reactome Reaction:
FGF18
→
FGFR2
(indirect_complex)
Stauber et al., Proc Natl Acad Sci U S A 2000, Yu et al., Proc Natl Acad Sci U S A 2000, Ibrahimi et al., Hum Mol Genet 2004, Pollock et al., Oncogene 2007, Dutt et al., Proc Natl Acad Sci U S A 2008, Byron et al., Cancer Res 2008, Byron et al., Gynecol Oncol 2010, Wilkie et al., Nat Genet 1995, Lomri et al., J Clin Invest 1998
-
Reactome Reaction:
FGF18
→
FGFR2
(direct_complex)
-
WikiPathways ESC Pluripotency Pathways:
FGF1/FGF16/FGF6/FGF19/FGF22/FGF10/FGF9/FGF20/FGF11/FGF17/FGF18/FGF14/FGF23/FGF5/FGF2/FGF12/FGF21/FGF3/FGF7/FGF8/FGF4
→
FGFR1/FGFR3/FGFR4/FGFR2
(activation)
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., Growth Factors 2000
:
The biological activities of
fibroblast growth factors ( FGF ) are
mediated by specific cell membrane receptors (
FGFR ), which have three immunoglobulin-like IgG domains in the extracellular region
Morriss-Kay et al., Novartis Found Symp 2001
(Craniosynostoses) :
Experimental increase of sutural
FGF levels
leads to down-regulation of
Fgfr2 , up-regulation of Fgfr1, up-regulation of the osteogenic differentiation gene Osteopontin, and cessation of proliferation
Pellegrini et al., Curr Opin Struct Biol 2001
:
Fibroblast growth factors ( FGFs ) are among the best studied heparin binding proteins, and heparan sulfate proteoglycans
regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor,
FGFR
Kubota et al., Bone 2002
:
On day 10,
FGF-4 was not
detected , whereas the expression of FGFR-1 and
FGFR-2 was detectable in the area of alkaline phosphatase (ALP) expression
Anderson et al., J Neurochem 2005
:
Dendrimeric FRM peptide was 125-fold more active and stimulated FGFR activation,
FGFR dependent and
FGF-mimetic neurite outgrowth and cell survival ( but not proliferation )
Buratini et al., Biol Reprod 2007
:
Whereas many FGFs activate several FGF receptors,
FGF7 and FGF10 primarily
activate only one,
FGFR2B ... Whereas many FGFs activate several FGF receptors,
FGF7 and FGF10 primarily
activate only one,
FGFR2B
Zhao et al., Clin Cancer Res 2010
(Carcinoma...) :
The capability of the mAbs to inhibit
FGF induced
FGFR2 phosphorylation and to downmodulate FGFR2 expression was also investigated
Li et al., Mol Cell Endocrinol 2012
:
In hepatocyte,
FGF-21 up-regulation
reduced HMGR and PEPCK mRNA expression and increased ß-klotho,
FGFR4 and LDLr expression ( p < 0.05 ), whereas down-regulation had the opposite effects
Ahmad et al., Biochim Biophys Acta 2012
(Cell Transformation, Neoplastic...) :
FGF signalling
mediated by
FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy
Itoh et al., Development 1996
:
These results suggest that the FGFR mediated
FGF signaling ( 1 ) blocks terminal differentiation of myogenic cells within the somite and ( 2 ) sustains myoblast migration to limb buds from the somite, and that ( 3 ) down-regulation of FGFRs or
FGFR signaling is
involved in mechanisms triggering terminal differentiation of the limb muscle mass during avian embryogenesis
McKeehan et al., Prog Nucleic Acid Res Mol Biol 1998
:
Divalent cations cooperate with the FGFRHS to conformationally restrict FGFRTK trans-phosphorylation, which causes depression of kinase activity and facilitates appropriate
activation of the
FGFR complex by
FGF