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FLT1 — MMP9

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of FLT1-VEGFA → MMP9 (increases, FLT1/VEGFA Activity)
  Evidence: a function of MMP9 is to render VEGF bioavailable to its receptors VEGF blockade inhibits bone repair
• OpenBEL Selventa BEL large corpus: Complex of FLT1-VEGFA → MMP9 (increases, FLT1/VEGFA Activity)
  Evidence: The matrix metalloproteinase (MMP)-9 was also found to be a component of the angiogenic switch. By releasing sequestered VEGF, this proteinase makes VEGF available for interaction with its receptors45.

Text-mined interactions from Literome

Yu et al., Cytotechnology 2009 : Matrine significantly reduced the invasion, MMP-9/MMP-2 activation , Akt phosphorylation, nuclear factor kappaB p-65 expression and DNA binding activity, and mRNA levels of MMP-9, MMP-2, EGF and VEGFR1 in MDA-MB-231 cells
Wang et al., Circ Res 1998 : These data suggest the role of flt-1 in mediating VEGF stimulated MMP expression of SMCs