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FOXO4 — INS

Text-mined interactions from Literome

Tsai et al., Endocrinology 2003 (Carcinoma, Hepatocellular...) : The activity of FOXO proteins is principally regulated by activation of protein kinase B (PKB)/Akt by insulin and other cytokines
Kino et al., Diabetes 2005 (Acquired Immunodeficiency Syndrome...) : This HIV-1 protein also interfered with insulin induced coprecipitation of 14-3-3 and Foxo3a in vivo and antagonized the negative effect of insulin on Foxo3a induced transactivation of a FOXO-responsive promoter
van der Heide et al., Trends Biochem Sci 2005 : Forkhead box, class O ( FoxO ) transcription factors are inhibited by insulin induced FoxO phosphorylation
Guo et al., Mol Endocrinol 2006 : By contrast, insulin stimulation of Irs1 ( -/- ) MEFs caused FoxO degradation, not only because Irs2 expression increased but also because Irs2 efficiently activated p110alpha -- > Akt cascade
Ni et al., Proc Natl Acad Sci U S A 2007 (Insulin Resistance) : Importantly, FoxO mediated increases in Akt activity diminish insulin signaling, as manifested by reduced Akt phosphorylation, reduced membrane translocation of Glut4, and decreased insulin triggered glucose uptake
Hansen et al., PLoS Genet 2008 : Long lived daf-2 insulin/IGF-1 receptor mutants require both autophagy and the transcription factor DAF-16/FOXO for their longevity, but we find that autophagy takes place in the absence of DAF-16
Cleveland et al., Am J Physiol Regul Integr Comp Physiol 2010 : IGF-I and insulin stimulated phosphorylation of FOXO1 and FOXO4 ( P < 0.05 ), which was inhibited by the phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor wortmannin, and decreased the abundance of polyubiquitinated proteins by 10-20 % ( P < 0.05 )
Kenyon et al., Ann N Y Acad Sci 2010 : However, the mechanisms by which inhibition of insulin/IGF-1 signaling and germline loss activate DAF-16/FOXO are distinct
Edmonds et al., Dev Cell 2010 : Reduction in insulin signaling activates DAF-16/FOXO , which represses the transcription of germline and intestinal genes required to deliver PUFAs to oocytes in lipoprotein complexes
Löw et al., Gen Comp Endocrinol 2011 (Nerve Degeneration) : Longevity increases when FoxO becomes activated in response to reduced insulin/IGF-1 signalling
Senapedis et al., Mol Biol Cell 2011 : Insulin/Akt activation directs phosphorylation and cytoplasmic sequestration of FOXO away from its target genes and serves as an endpoint of a complex signaling network
Yamamoto et al., Aging Cell 2011 : Although extensively studied in Caenorhabditis elegans, no work has yet demonstrated for Drosophila melanogaster whether reduced insulin/IGF signaling (IIS) requires the FOXO transcription factor ( foxo ) to extend lifespan
Mansisidor et al., PLoS Genet 2011 : Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness
Putker et al., Mol Cell 2013 : We show that disulfide formation with transportin-1 is required for nuclear localization and the activation of FOXO4/DAF-16 induced by ROS, but not by the loss of insulin signaling