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FOXO4 — TNFSF10

Text-mined interactions from Literome

Park et al., Cell Signal 2009 : In this study, we found that TRAIL inhibited PI3K/Akt dependent FoxO phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells ... Collectively, our data suggest that sequential activation of FoxO proteins under conditions of suppressed PI3K/Akt signaling by TRAIL can down-regulate c-FLIP ( L/S ), consequently promoting TRAIL induced apoptosis in LX-2 cells
Chen et al., PloS one 2010 (Prostatic Neoplasms) : The inhibition of PI3K/AKT pathway induced FOXO transcriptional activity resulting in induction of Bim, TRAIL , p27/KIP1, DR4 and DR5, and inhibition of cyclin D1
Keniry et al., Genes Dev 2013 (Breast Neoplasms) : To gain insight into how FOXOs select specific genes for regulation, we performed a screen for genes that modify FOXO activation of TRAIL , a death receptor ligand capable of inducing extrinsic apoptosis