Hoe et al., J Biol Chem 2008
:
Fyn induced phosphorylation of APP at Tyr-757 of the ( 757 ) YENPTY ( 762 ) motif and increased cell surface expression of APP ... Fyn induced APP phosphorylation and cell surface levels of APP were potentiated in the presence of Dab1
Minami et al., Neurobiol Aging 2012
(Alzheimer Disease...) :
However, Fyn also increases the nonpathological cleavage of amyloid precursor protein (APP) , suggesting opposing roles for Fyn in the pathogenesis of Alzheimer 's disease ( AD )