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FYN — PI3
Text-mined interactions from Literome
Ciprés et al., J Biol Chem 2003
:
We have studied alternative receptor derived signals to explain calcium independent DAGK alpha activation, and show that DAGK alpha is stimulated by
Src-like kinase dependent
phosphoinositide 3 kinase (PI3K) activation in lymphocytes
Karnitz et al., J Exp Med 1994
:
Previous studies have described a physical association between Fyn and a potential downstream substrate, phosphatidylinositol 3-kinase ( PI3-kinase ) as well as the IL-2 dependent activation of PI3-kinase in T cells ; however, the
role of
Fyn in IL-2 induced
PI3-kinase activation remains unclear ... Furthermore, overexpression of wild-type
Fyn in these cells
enhanced both the basal and IL-2 mediated activation of
PI3-kinase