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GAL — TNF
Text-mined interactions from Literome
Muntané et al., J Gastroenterol Hepatol 1998
(Drug-Induced Liver Injury) :
Also,
D-GalN increased alanine aminotransferase ( ALT ), aspartate aminotransferase (AST), alkaline phosphatase and
TNF-alpha in serum compared with the control group
Bovin et al., FEBS Lett 1999
:
Gal-cer also
increased TNF secretion
Endo et al., Br J Pharmacol 1999
(Drug-Induced Liver Injury) :
Administration of a macrophage depletor, liposomes encapsulated with dichloromethylene bisphosphonate, reduced both the
TNF production and mortality
induced by
GalN+LPS ... 4. Serum from LPS injected mice reduced the
TNF production
induced by
GalN+LPS , but it was less effective at reducing the lethality
Bang et al., J Pharmacol Exp Ther 2003
(Drug-Induced Liver Injury...) :
NK-1R blockade clearly inhibited
GalN/LPS induced production of
TNFalpha and IFNgamma, whereas synthesis of the hepatoprotective cytokines IL-6 and IL-10 was increased
Ait-Ali et al., Mol Endocrinol 2004
:
TNF-alpha and IL-1
induced a time- and dose dependent increase in
galanin , vasoactive intestinal polypeptide, and secretogranin II mRNA levels
Masaki et al., Hepatology 2004
(Drug-Induced Liver Injury...) :
In addition, pretreatment with adiponectin attenuated the
GalN/LPS induced increases in serum and hepatic
tumor necrosis factor alpha (TNF-alpha) levels and increased peroxisome proliferator activated receptor ( PPAR) alpha messenger RNA expression in the liver
Masaki et al., FASEB J 2005
(Necrosis) :
Histamine attenuated the
GalN/LPS induced increases in the levels of
TNF-alpha , but augmented those of IL-10 both in the liver and serum
Dallos et al., Neuropeptides 2006
(Inflammation) :
The aims of this study were a systematic investigation of the
effects of the neuropeptides substance P ( SP ), calcitonin gene related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and
galanin (GAL) on the inflammatory cytokine production ( IL-1alpha, IL-8 and
TNF-alpha ) of the keratinocytes, and a study of their role in the production and secretion of nerve growth factor (NGF) and its precursor molecule ( proNGF )
Wan et al., Eur J Pharmacol 2008
(Drug-Induced Liver Injury) :
Baicalin reduced nuclear translocation of NF-kappa B, TNF-alpha mRNA and protein levels in hepatic tissues and plasma levels of
TNF-alpha induced by
LPS/D-GalN
Lee et al., Food Chem Toxicol 2010
(Liver Failure, Acute) :
GalN/LPS increased the circulating levels of
tumor necrosis factor (TNF)-alpha , interleukin-6 (IL-6) and IL-10
Colomb et al., Biochimie 2012
:
Herein, we show that the pro-inflammatory cytokine
TNF increases the expression of a2,3-sialyltransferase gene
ST3GAL4 , both in human bronchial mucosa and in A549 lung carcinoma cells
Kim et al., J Ethnopharmacol 2013
(Liver Failure) :
GalN/LPS increased serum aminotransferase activity, serum
tumor necrosis factor-a level and hepatic lipid peroxidation and decreased hepatic glutathione content
Dong et al., Mol Med Report 2013
(Drug-Induced Liver Injury) :
IBFF attenuated the
D-Gal induced increases in
tumor necrosis factor-a (TNF-a), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein levels in the liver
Czaja et al., Am J Physiol 1994
:
The
effects of the hepatotoxin
D-galactosamine (GalN) and lipopolysaccharide (LPS) on hepatic and splenic
TNF-alpha and MnSOD expression were studied
Séguin et al., Proc Natl Acad Sci U S A 1995
:
Polyclonal anti-lectin serum specifically inhibited
TNF-alpha mRNA induction in
response to the
Gal-lectin but not to lipopolysaccharide ... Anti-lectin monoclonal antibodies 8C12, H85 and 1G7, which recognize nonoverlapping epitopes of the cysteine-rich region of the 170-kDa heavy subunit, inhibited both amebic adherence to mammalian cells and
Gal-lectin stimulated
TNF-alpha mRNA expression by BMMs, but monoclonal antibody 7F4 did neither
Séguin et al., Infect Immun 1997
(Entamoebiasis) :
Native
Gal-lectin ( 100 to 500 ng/ml )
stimulated TNF-alpha and inducible nitric oxide synthase (iNOS) mRNA expression in IFN-gamma primed BMM as did lipopolysaccharide ( 100 ng/ml ) ... Primed BMM produced
TNF-alpha and NO in
response to
Gal-lectin in a dose dependent manner ... Antilectin monoclonal antibody IG7, which recognizes a domain ( amino acids 596 to 818 ) of the TNF-alpha mRNA stimulating region of Gal-lectin, specifically inhibited
TNF-alpha and iNOS mRNA induction and TNF-alpha and NO production by primed BMM in
response to
Gal-lectin ( 100 ng/ml )
Baumhofer et al., Eur J Immunol 1998
(Endotoxemia...) :
Gene transfer with hIL-4 reduced the serum
tumor necrosis factor (TNF)-alpha production in
response to
endotoxin/D-GalN by 80 % from 113.1 pg/ml in mock transfected animals to 22.2 pg/ml ( p < 0.05 ) ; human IL-13 gene transfer reduced serum TNF-alpha levels by 90 % ( 113.1 pg/ml to 11.6 pg/ml ; p < 0.05 )