Gene interactions and pathways from curated databases and text-mining

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GAL — TNF

Text-mined interactions from Literome

Muntané et al., J Gastroenterol Hepatol 1998 (Drug-Induced Liver Injury) : Also, D-GalN increased alanine aminotransferase ( ALT ), aspartate aminotransferase (AST), alkaline phosphatase and TNF-alpha in serum compared with the control group
Bovin et al., FEBS Lett 1999 : Gal-cer also increased TNF secretion
Endo et al., Br J Pharmacol 1999 (Drug-Induced Liver Injury) : Administration of a macrophage depletor, liposomes encapsulated with dichloromethylene bisphosphonate, reduced both the TNF production and mortality induced by GalN+LPS ... 4. Serum from LPS injected mice reduced the TNF production induced by GalN+LPS , but it was less effective at reducing the lethality
Bang et al., J Pharmacol Exp Ther 2003 (Drug-Induced Liver Injury...) : NK-1R blockade clearly inhibited GalN/LPS induced production of TNFalpha and IFNgamma, whereas synthesis of the hepatoprotective cytokines IL-6 and IL-10 was increased
Ait-Ali et al., Mol Endocrinol 2004 : TNF-alpha and IL-1 induced a time- and dose dependent increase in galanin , vasoactive intestinal polypeptide, and secretogranin II mRNA levels
Masaki et al., Hepatology 2004 (Drug-Induced Liver Injury...) : In addition, pretreatment with adiponectin attenuated the GalN/LPS induced increases in serum and hepatic tumor necrosis factor alpha (TNF-alpha) levels and increased peroxisome proliferator activated receptor ( PPAR) alpha messenger RNA expression in the liver
Masaki et al., FASEB J 2005 (Necrosis) : Histamine attenuated the GalN/LPS induced increases in the levels of TNF-alpha , but augmented those of IL-10 both in the liver and serum
Dallos et al., Neuropeptides 2006 (Inflammation) : The aims of this study were a systematic investigation of the effects of the neuropeptides substance P ( SP ), calcitonin gene related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and galanin (GAL) on the inflammatory cytokine production ( IL-1alpha, IL-8 and TNF-alpha ) of the keratinocytes, and a study of their role in the production and secretion of nerve growth factor (NGF) and its precursor molecule ( proNGF )
Wan et al., Eur J Pharmacol 2008 (Drug-Induced Liver Injury) : Baicalin reduced nuclear translocation of NF-kappa B, TNF-alpha mRNA and protein levels in hepatic tissues and plasma levels of TNF-alpha induced by LPS/D-GalN
Lee et al., Food Chem Toxicol 2010 (Liver Failure, Acute) : GalN/LPS increased the circulating levels of tumor necrosis factor (TNF)-alpha , interleukin-6 (IL-6) and IL-10
Colomb et al., Biochimie 2012 : Herein, we show that the pro-inflammatory cytokine TNF increases the expression of a2,3-sialyltransferase gene ST3GAL4 , both in human bronchial mucosa and in A549 lung carcinoma cells
Kim et al., J Ethnopharmacol 2013 (Liver Failure) : GalN/LPS increased serum aminotransferase activity, serum tumor necrosis factor-a level and hepatic lipid peroxidation and decreased hepatic glutathione content
Dong et al., Mol Med Report 2013 (Drug-Induced Liver Injury) : IBFF attenuated the D-Gal induced increases in tumor necrosis factor-a (TNF-a), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein levels in the liver
Czaja et al., Am J Physiol 1994 : The effects of the hepatotoxin D-galactosamine (GalN) and lipopolysaccharide (LPS) on hepatic and splenic TNF-alpha and MnSOD expression were studied
Séguin et al., Proc Natl Acad Sci U S A 1995 : Polyclonal anti-lectin serum specifically inhibited TNF-alpha mRNA induction in response to the Gal-lectin but not to lipopolysaccharide ... Anti-lectin monoclonal antibodies 8C12, H85 and 1G7, which recognize nonoverlapping epitopes of the cysteine-rich region of the 170-kDa heavy subunit, inhibited both amebic adherence to mammalian cells and Gal-lectin stimulated TNF-alpha mRNA expression by BMMs, but monoclonal antibody 7F4 did neither
Séguin et al., Infect Immun 1997 (Entamoebiasis) : Native Gal-lectin ( 100 to 500 ng/ml ) stimulated TNF-alpha and inducible nitric oxide synthase (iNOS) mRNA expression in IFN-gamma primed BMM as did lipopolysaccharide ( 100 ng/ml ) ... Primed BMM produced TNF-alpha and NO in response to Gal-lectin in a dose dependent manner ... Antilectin monoclonal antibody IG7, which recognizes a domain ( amino acids 596 to 818 ) of the TNF-alpha mRNA stimulating region of Gal-lectin, specifically inhibited TNF-alpha and iNOS mRNA induction and TNF-alpha and NO production by primed BMM in response to Gal-lectin ( 100 ng/ml )
Baumhofer et al., Eur J Immunol 1998 (Endotoxemia...) : Gene transfer with hIL-4 reduced the serum tumor necrosis factor (TNF)-alpha production in response to endotoxin/D-GalN by 80 % from 113.1 pg/ml in mock transfected animals to 22.2 pg/ml ( p < 0.05 ) ; human IL-13 gene transfer reduced serum TNF-alpha levels by 90 % ( 113.1 pg/ml to 11.6 pg/ml ; p < 0.05 )