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Rasmussen et al., Neurogastroenterol Motil 2001 : Effect of calcitonin gene related peptide (CGRP) on motility and on the release of substance P, neurokinin A, somatostatin and gastrin in the isolated perfused porcine antrum ... We studied the effect of porcine CGRP ( pCGRP ) in concentrations from 10 ( -10 ) to 10 ( -8 ) mol L ( -1 ) on the motility and on the release of substance P, neurokinin A, somatostatin and gastrin in the antrum using the isolated perfused porcine antrum as experimental model
Ren et al., Am J Physiol 1992 : These data suggest that the inhibitory effects of CGRP on cholinergic discharge and gastrin release are due to the paracrine effects of somatostatin released from antral D cells by direct action of CGRP
Kim et al., Nihon Naibunpi Gakkai Zasshi 1987 (Carcinoma...) : These findings suggest that fewer patients with medullary thyroid carcinoma than reported previously have high plasma levels of CGRP, either in the basal state or in response to calcium or gastrin , and that the levels of CGRP in the cerebrospinal fluid of normal subjects are very low
Manela et al., Gastroenterology 1995 : The aim of this study was to determine whether endogenous CGRP was involved , by a neurocrine mechanism, in acid mediated stimulation of somatostatin and inhibition of gastrin release ... CGRP8-37 inhibited significantly basal somatostatin ( -36 % ) and stimulated basal gastrin ( +65 % ) release ( P < 0.02 ) ... These results indicate that CGRP8-37 prevented acid mediated feedback inhibition of gastrin release and acid induced feedforward somatostatin release
Ren et al., Regul Pept 1998 : Somatostatin monoclonal antibody prevented CGRP mediated inhibition of both gastrin release and gastrin mRNA levels