Gene interactions and pathways from curated databases and text-mining

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AKT1 — GHSR

Text-mined interactions from Literome

Duxbury et al., Biochem Biophys Res Commun 2003 (Adenocarcinoma...) : D-Lys-GHRP6 suppressed ghrelin induced proliferation, invasion, and Akt phosphorylation
Frago et al., J Neuroendocrinol 2005 : In control rats, immunoreactive pAkt was practically undetectable ; however, GHRP-6 increased p-Akt immunoreactivity in the arcuate nucleus, with a subset of neurones also being immunoreactive for NPY
Pazos et al., Vitam Horm 2008 : At molecular level, GHSR1a regulates the activation of the downstream mitogen activated protein kinase, Akt , nitric oxide synthase, and AMPK cascades in different cellular systems
Duran-Prado et al., Circ Res 2013 (Atherosclerosis...) : Cortistatin inhibited platelet derived growth factor stimulated proliferation of human aortic SMCs via binding to somatostatin receptors ( sst2 and sst5 ) and ghrelin receptor , induction of cAMP and p38-mitogen activated protein kinase, and inhibition of Akt activity