Gene interactions and pathways from curated databases and text-mining

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GNRH2 — MAPK9

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2001 (Calcium Signaling) : In pituitary gonadotropes, gonadotropin releasing hormone (GnRH) activates all three major mitogen activated protein kinase ( MAPK ) cascades
Shah et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Dependence of gonadotropin releasing hormone induced neuronal MAPK signaling on epidermal growth factor receptor transactivation
Kim et al., J Clin Endocrinol Metab 2004 (Adenocarcinoma...) : In this study, the effect of GnRH-II on the activation of p38 MAPK was investigated, and its possible role in the regulation of cell proliferation and apoptosis was further examined in the human ovarian cancer cell line, OVCAR-3 ... The activation of p38 MAPK by GnRH-II was reversed in the presence of a specific inhibitor of p38 MAPK, SB203580 ( 1 microM )
Kim et al., J Clin Endocrinol Metab 2005 (Adenocarcinoma...) : We have previously demonstrated that GnRH-II activates p38 MAPK
Eicke et al., Int J Oncol 2006 (Endometrial Neoplasms...) : We showed that [ D-Lys6 ] GnRH-II reduces EGF induced auto-tyrosine-phosphorylation of EGF-receptors via activation of a PTP and that EGF induced activation of mitogen activated protein kinase was blocked in cells treated with [ D-Lys6 ] GnRH-II
Xie et al., Endocrinology 2008 (MAP Kinase Signaling System) : 3 ', 5'-cyclic adenosine 5'-monophosphate response element dependent transcriptional regulation of the secretogranin II gene promoter depends on gonadotropin releasing hormone induced mitogen activated protein kinase activation and the transactivator activating transcription factor 3
Wu et al., Cancer Res 2009 (Endometrial Neoplasms) : GnRH-II activated extracellular signal regulated kinase ( ERK)-1/2 and p38 mitogen activated protein kinase ( MAPK ) in a time dependent manner, and the activation was abolished by GnRH-I receptor siRNA and MAPK inhibitors
Sundaresan et al., Endocrinology 1996 : Stimulation of mitogen activated protein kinase by gonadotropin releasing hormone : evidence for the involvement of protein kinase C