Ma et al., Int J Oncol 2006
:
Additionally, PHI reduced the expression of HDAC and increased the level of acetyl transferase p300, in favor of accumulation of acetylated histones
Beklemisheva et al., Anticancer Res 2006
(Prostatic Neoplasms) :
PHI inhibited the activity of HDAC and remodeled chromatins to activate p21 for cell cycle arrest, underlying an epigenetic mechanism regulating the growth of prostate cancer cells