Gene interactions and pathways from curated databases and text-mining

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GPR152 — GRK4

Text-mined interactions from Literome

Tesmer et al., Science 2005 : G protein coupled receptor kinase 2 ( GRK2 ) plays a key role in the desensitization of G protein coupled receptor signaling by phosphorylating activated heptahelical receptors and by sequestering heterotrimeric G proteins
Mariggiò et al., Cell Signal 2006 : G-protein-coupled-receptor kinase 2 ( GRK2 ) plays a key role in the modulation of G-protein-coupled-receptor ( GPCR ) signaling by both phosphorylating agonist occupied GPCRs and by directly binding to activated Galphaq subunits, inhibiting downstream effectors activation
Cobelens et al., Cell Signal 2007 (Glioma) : G protein coupled receptor kinase 2 ( GRK2 ) plays a key role in G protein coupled receptor ( GPCR ) signaling modulation, and its expression levels are decreased after brain hypoxia/ischemia and reperfusion as well as in several inflammatory conditions
Wang et al., J Biol Chem 2008 : This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how G protein coupled receptor signaling may be finely regulated by GRK in physiological settings
Namkung et al., J Biol Chem 2009 : Our results suggest a novel mechanism by which GRK2 negatively regulates G protein coupled receptor signaling in a manner that is independent of receptor phosphorylation
Penela et al., Proc Natl Acad Sci U S A 2010 : G protein coupled receptor kinase 2 ( GRK2 ) plays a central role in G protein coupled receptor regulation