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Li et al., J Biol Chem 2010
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Mechanistic investigations have shown that as a G ( i ) -coupled receptor, GPR109A inhibits adenylate cyclase activity upon niacin activation, thereby inhibiting free fatty acid liberation
Li et al., J Biol Chem 2011
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Mechanistic investigations have shown that, upon niacin activation, GPR109A couples to a G(i) protein and inhibits adenylate cyclase activity, leading to inhibition of liberation of free fatty acid
Jalink et al., Cell Growth Differ 1993
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LPA stimulates phospholipase C and inhibits adenylate cyclase in its target cells, apparently by activating a specific G-protein coupled receptor