◀ Back to TP53
GPX1 — TP53
Text-mined interactions from Literome
Tan et al., J Biol Chem 1999
:
Transcriptional
activation of the human
glutathione peroxidase promoter by
p53 ... In a search for a cis-element that confers potential
p53 regulation of
GPX , we identified a p53 binding site in the promoter of the GPX gene ... The
p53 binding and
transactivation of the
GPX promoter were enhanced by etoposide in p53 positive U2-OS cells ... Etoposide induced transactivation was blocked by a dominant negative p53 mutant, indicating that endogenous wild type
p53 , upon activation by etoposide,
transactivated the
GPX promoter
Hussain et al., Cancer Res 2004
:
p53 induced
up-regulation of MnSOD and
GPx but not catalase increases oxidative stress and apoptosis ... Microarray expression analysis of doxorubicin exposed, related human lymphoblasts, p53 wild-type ( WT ) Tk6, and p53 mutant WTK1 identified the
p53 dependent up-regulation of manganese superoxide dismutase ( MnSOD ) and
glutathione peroxidase 1 (GPx) ... These results identify a novel mechanism of p53 dependent apoptosis in which
p53 mediated up-regulation of MnSOD and
GPx , but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress
Gladyshev et al., Biochem Biophys Res Commun 1998
(Carcinoma, Hepatocellular...) :
In the colon cell line,
p53 expression
resulted in elevated
GPX1 , but repressed TR