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GRB10 — VEGFA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → NEDD4/GRB10 complex (NEDD4-GRB10) (degradation, collaborate)
  Giorgetti-Peraldi et al., Oncogene 2001, Murdaca et al., J Biol Chem 2004, Hasseine et al., Exp Cell Res 2007
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Giorgetti-Peraldi et al., Oncogene 2001 (MAP Kinase Signaling System) : An intact SH2 domain is required for Grb10 tyrosine phosphorylation in response to VEGF , and this phosphorylation is mediated in part through the activation of Src ... In HUVEC, VEGF increases Grb10 mRNA level
Murdaca et al., J Biol Chem 2004 : Grb10 prevents Nedd4 mediated vascular endothelial growth factor receptor-2 degradation ... Indeed, VEGF stimulates Grb10 expression, and Grb10 overexpression induces an increase in the amount and the tyrosine phosphorylation of VEGF-R2 ... Co-expression of Nedd4 and Grb10 restores the expression of VEGF-R2, suggesting that Grb10 inhibits the Nedd4 mediated degradation of VEGF-R2