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GSK3B — LEP
Text-mined interactions from Literome
PĂ©rez et al., Diabetes 2004
:
However, at elevated concentrations,
leptin impaired insulin stimulated MAPK activity,
glycogen synthase kinase (GSK)3beta phosphorylation, and insulin receptor tyrosine phosphorylation without altering vanadate stimulation
Brabant et al., FASEB J 2005
(Insulin Resistance...) :
Only in lean animals phosphorylation of PKB ( T308 ) and
GSK-3beta ( S9 ) was acutely
stimulated by
leptin at 45 min followed by inhibition at 6 h after application
Valerio et al., J Biol Chem 2006
:
Leptin mediated
GSK3beta phosphorylation was prevented by the MEK/ERK inhibitor PD98059, the phosphatidylinositol 3-kinase inhibitor LY294002, or the protein kinase C inhibitor GF109203X
Greco et al., Neurosci Lett 2009
(Alzheimer Disease) :
Leptin inhibits
glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells