Gene interactions and pathways from curated databases and text-mining

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GSK3B — LEP

Text-mined interactions from Literome

PĂ©rez et al., Diabetes 2004 : However, at elevated concentrations, leptin impaired insulin stimulated MAPK activity, glycogen synthase kinase (GSK)3beta phosphorylation, and insulin receptor tyrosine phosphorylation without altering vanadate stimulation
Brabant et al., FASEB J 2005 (Insulin Resistance...) : Only in lean animals phosphorylation of PKB ( T308 ) and GSK-3beta ( S9 ) was acutely stimulated by leptin at 45 min followed by inhibition at 6 h after application
Valerio et al., J Biol Chem 2006 : Leptin mediated GSK3beta phosphorylation was prevented by the MEK/ERK inhibitor PD98059, the phosphatidylinositol 3-kinase inhibitor LY294002, or the protein kinase C inhibitor GF109203X
Greco et al., Neurosci Lett 2009 (Alzheimer Disease) : Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells