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H6PD — INS
Text-mined interactions from Literome
Xu et al., Diabetes 2001
:
It has been previously established that leucine induced
insulin secretion by beta-cells
involves increased mitochondrial metabolism by oxidative decarboxylation and allosteric activation of
glutamate dehydrogenase (GDH)
Lee et al., Mol Cells 2004
:
Although the relation between GDH activity and insulin release remains to be clarified, our results suggest that C. heracleifolia extract
regulates insulin release by altering
GDH activity in primary cultured islets and that this natural compound may be used to modulate GDH activity in patients with hyperinsulinism-hyperammonemia syndrome
Li et al., J Biol Chem 2006
(Calcium Signaling...) :
Glutamate dehydrogenase (GDH) plays an important role in
insulin secretion as evidenced in children by gain of function mutations of this enzyme that cause a hyperinsulinism-hyperammonemia syndrome ( GDH-HI ) and sensitize beta-cells to leucine stimulation ... H454Y
GDH transgenic islets were more sensitive to leucine- and glutamine
stimulated insulin secretion but had decreased response to glucose stimulation
Lee et al., Obesity (Silver Spring) 2008
:
However, in Om only,
hexose-6-phosphate dehydrogenase (H6PDH) mRNA levels were
increased by culture with dexamethasone plus
insulin compared to insulin alone, suggesting that higher nicotinamide adenine dinucleotide phosphate-oxidase ( NADPH ) production within the endoplasmic reticulum ( ER ) contributed to the higher HSD reductase activity
Li et al., J Biol Chem 2009
:
The recently discovered hyperinsulinism/hyperammonemia disorder showed that the loss of allosteric inhibition of
GDH by GTP
causes excessive secretion of
insulin
Yang et al., BMB Rep 2010
:
Our results show that KHG26377
regulates insulin release by inhibiting
GDH activity in primary cultured islets and support the previous studies for the connection between GDH activity and insulin release
Li et al., Neurochem Int 2011
:
Finally, several compounds have been identified that block
GDH mediated
insulin secretion that may be to not only find use in treating these insulin disorders but to kill tumors that require glutamine metabolism for cellular energy
Stanley et al., Neurochem Int 2011
(Hyperammonemia...) :
These two novel human disorders demonstrate the important
role of
GDH in
insulin regulation and illustrate unexpectedly important reasons for the unusually complex allosteric regulation of GDH
Li et al., J Biol Chem 2011
:
We have previously shown that two of the polyphenols from green tea ( epigallocatechin gallate ( EGCG ) and epicatechin gallate ( ECG ) ) inhibit GDH in vitro and that EGCG blocks
GDH mediated
insulin secretion in wild type rat islets
da Silva et al., Metabolism 2012
(Body Weight...) :
In addition,
GDH may
contribute to
insulin secretion through ameliorations of Ca ( 2+ ) handling in LP islets
Heslegrave et al., J Clin Endocrinol Metab 2013
(Metabolism, Inborn Errors) :
This is caused by a loss of protein/protein interaction between short-chain HADH ( SCHAD, the enzyme coded for by HADH ) and
GDH , causing an overstimulation of GDH and a rise in cellular ATP and
up-regulated insulin secretion