Gene interactions and pathways from curated databases and text-mining

◀ Back to INS

H6PD — INS

Text-mined interactions from Literome

Xu et al., Diabetes 2001 : It has been previously established that leucine induced insulin secretion by beta-cells involves increased mitochondrial metabolism by oxidative decarboxylation and allosteric activation of glutamate dehydrogenase (GDH)
Lee et al., Mol Cells 2004 : Although the relation between GDH activity and insulin release remains to be clarified, our results suggest that C. heracleifolia extract regulates insulin release by altering GDH activity in primary cultured islets and that this natural compound may be used to modulate GDH activity in patients with hyperinsulinism-hyperammonemia syndrome
Li et al., J Biol Chem 2006 (Calcium Signaling...) : Glutamate dehydrogenase (GDH) plays an important role in insulin secretion as evidenced in children by gain of function mutations of this enzyme that cause a hyperinsulinism-hyperammonemia syndrome ( GDH-HI ) and sensitize beta-cells to leucine stimulation ... H454Y GDH transgenic islets were more sensitive to leucine- and glutamine stimulated insulin secretion but had decreased response to glucose stimulation
Lee et al., Obesity (Silver Spring) 2008 : However, in Om only, hexose-6-phosphate dehydrogenase (H6PDH) mRNA levels were increased by culture with dexamethasone plus insulin compared to insulin alone, suggesting that higher nicotinamide adenine dinucleotide phosphate-oxidase ( NADPH ) production within the endoplasmic reticulum ( ER ) contributed to the higher HSD reductase activity
Li et al., J Biol Chem 2009 : The recently discovered hyperinsulinism/hyperammonemia disorder showed that the loss of allosteric inhibition of GDH by GTP causes excessive secretion of insulin
Yang et al., BMB Rep 2010 : Our results show that KHG26377 regulates insulin release by inhibiting GDH activity in primary cultured islets and support the previous studies for the connection between GDH activity and insulin release
Li et al., Neurochem Int 2011 : Finally, several compounds have been identified that block GDH mediated insulin secretion that may be to not only find use in treating these insulin disorders but to kill tumors that require glutamine metabolism for cellular energy
Stanley et al., Neurochem Int 2011 (Hyperammonemia...) : These two novel human disorders demonstrate the important role of GDH in insulin regulation and illustrate unexpectedly important reasons for the unusually complex allosteric regulation of GDH
Li et al., J Biol Chem 2011 : We have previously shown that two of the polyphenols from green tea ( epigallocatechin gallate ( EGCG ) and epicatechin gallate ( ECG ) ) inhibit GDH in vitro and that EGCG blocks GDH mediated insulin secretion in wild type rat islets
da Silva et al., Metabolism 2012 (Body Weight...) : In addition, GDH may contribute to insulin secretion through ameliorations of Ca ( 2+ ) handling in LP islets
Heslegrave et al., J Clin Endocrinol Metab 2013 (Metabolism, Inborn Errors) : This is caused by a loss of protein/protein interaction between short-chain HADH ( SCHAD, the enzyme coded for by HADH ) and GDH , causing an overstimulation of GDH and a rise in cellular ATP and up-regulated insulin secretion