◀ Back to RAC1
HIF1A — RAC1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
HIF1A
→
RAC1
(increases, HIF1A Activity)
Evidence: increases protein - ligands of other receptors (thrombin, angiotensin), RAS expression, small G-protein RAC1, PTEN inhibition, diacyl glycerol kinase
Text-mined interactions from Literome
Hirota et al., J Biol Chem 2001
:
We report here that the small GTPase
Rac1 is activated in response to hypoxia and is
required for the induction of
HIF-1alpha protein expression and transcriptional activity in hypoxic cells
Xue et al., Int J Cancer 2006
(Carcinoma, Hepatocellular...) :
Role of
Rac1 and Cdc42 in hypoxia
induced p53 and von Hippel-Lindau suppression and
HIF1alpha activation
Diebold et al., Antioxid Redox Signal 2010
:
Reciprocal
regulation of
Rac1 and PAK-1 by
HIF-1alpha : a positive-feedback loop promoting pulmonary vascular remodeling