◀ Back to TP53
HIF1A — TP53
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
HIF1A
→
TP53
(decreases, TP53 Activity, HIF1A Activity)
Evidence: p53 directly interacts with HIF1A and blocks HIF1A's ability to activate transcription
-
OpenBEL Selventa BEL large corpus:
HIF1A
→
Complex of HIF1A-TP53
(decreases, HIF1A/TP53 Activity)
Evidence: during hypoxia-induced apoptosis, only the phosphorylated HIF1A binds ARNT the dephosphorylated form of HIF1A binds p53 and induces apoptosis
-
BioCarta hypoxia and p53 in the cardiovascular system:
MDM2
→
ubiquitin/p53/E2/HIF-1-alpha complex (TP53-UBE2A-HIF1A)
(modification, activates)
-
BioCarta hypoxia and p53 in the cardiovascular system:
ubiquitin/p53/E2 complex (TP53-UBE2A)
→
ubiquitin/p53/E2/HIF-1-alpha complex (TP53-UBE2A-HIF1A)
(modification, collaborate)
-
BioCarta hypoxia and p53 in the cardiovascular system:
ubiquitin/p53/E2 complex (TP53-UBE2A)
→
HIF-1-alpha (HIF1A)
(modification, collaborate)
-
BioCarta hypoxia and p53 in the cardiovascular system:
ubiquitin/p53/E2/HIF-1-alpha complex (TP53-UBE2A-HIF1A)
→
HIF-1-alpha (HIF1A)
(modification, collaborate)
-
BioCarta hypoxia and p53 in the cardiovascular system:
HIF-1-alpha/ubiquitin complex (HIF1A)
→
ubiquitin/p53/E2/HIF-1-alpha complex (TP53-UBE2A-HIF1A)
(protein ubiquitination, collaborate)
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/p53 complex (HIF1A-TP53)
→
p53 (TP53)
(modification, collaborate)
Bae et al., J Biol Chem 2002*, An et al., Nature 1998*
Evidence: physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/p53 complex (HIF1A-TP53)
→
HIF1A (HIF1A)
(modification, collaborate)
Bae et al., J Biol Chem 2002*, An et al., Nature 1998*
Evidence: physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/p53 complex (HIF1A-TP53)
→
JAB1 (COPS5)
(modification, collaborate)
Bae et al., J Biol Chem 2002*, An et al., Nature 1998*
Evidence: physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
HIF1A/p53 complex (HIF1A-TP53)
→
HIF1A/JAB1 complex (HIF1A-COPS5)
(modification, collaborate)
Bae et al., J Biol Chem 2002*, An et al., Nature 1998*
Evidence: physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
p53 (TP53)
→
HIF1A (HIF1A)
(modification, collaborate)
Bae et al., J Biol Chem 2002*, An et al., Nature 1998*
Evidence: physical interaction
-
NCI Pathway Database Hypoxic and oxygen homeostasis regulation of HIF-1-alpha:
p53 (TP53)
→
HIF1A/JAB1 complex (HIF1A-COPS5)
(modification, collaborate)
Bae et al., J Biol Chem 2002*, An et al., Nature 1998*
Evidence: physical interaction
-
WikiPathways Photodynamic therapy-induced HIF-1 survival signaling:
ARNT/HIF1A
→
BNIP3/BNIP3L/BID/PMAIP1/TP53/BAX/BAK1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
HIF1A
—
TP53
Sánchez-Puig et al., Mol Cell 2005*
-
IRef Bind Interaction:
HIF1A
—
TP53
Suzuki et al., Oncogene 2001*
-
IRef Bind_translation Interaction:
HIF1A
—
TP53
(experimental interaction detection)
Sánchez-Puig et al., Mol Cell 2005*
-
IRef Bind_translation Interaction:
HIF1A
—
TP53
(coimmunoprecipitation)
Suzuki et al., Oncogene 2001*
-
IRef Bind_translation Interaction:
HIF1A
—
TP53
(fluorescence polarization spectroscopy)
Sánchez-Puig et al., Mol Cell 2005*
-
IRef Biogrid Interaction:
HIF1A
—
TP53
(physical association, affinity chromatography technology)
Chen et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
HIF1A
—
TP53
(direct interaction, pull down)
Hansson et al., Proc Natl Acad Sci U S A 2002*
-
IRef Biogrid Interaction:
HIF1A
—
TP53
(physical association, affinity chromatography technology)
Ravi et al., Genes Dev 2000*
-
IRef Biogrid Interaction:
HIF1A
—
TP53
(physical association, affinity chromatography technology)
An et al., Nature 1998*
-
IRef Hprd Interaction:
TP53
—
HIF1A
(in vitro)
Hansson et al., Proc Natl Acad Sci U S A 2002*, An et al., Nature 1998*
-
IRef Ophid Interaction:
HIF1A
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ravi et al., Genes Dev 2000
(Adenocarcinoma...) :
Loss of
p53 in tumor cells
enhances HIF-1alpha levels and augments HIF-1 dependent transcriptional activation of the vascular endothelial growth factor ( VEGF ) gene in response to hypoxia
Suzuki et al., Oncogene 2001
:
Depletion of the dephosphorylated
HIF-1alpha , by using the Hsp90 inhibitor geldanamycin A that had little effect on the phosphorylated HIF-1alpha expression,
suppressed p53 induction and subsequent apoptosis
Chen et al., J Biol Chem 2003
(Anoxia) :
These results have significant implications regarding the molecular mechanism by which
p53 is
activated by
HIF-1 alpha in response to hypoxia
Kaluzová et al., Mol Cell Biol 2004
(Anoxia) :
DNA damage is a prerequisite for
p53 mediated proteasomal degradation of
HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX ... The activated
p53 mediated
increased proteasomal degradation of HIF-1alpha protein, resulting in considerably lower steady-state levels of
HIF-1alpha protein in hypoxic MCF-7 cells but not in Saos-2 cells
Demidenko et al., Oncogene 2005
:
Under normoxia, while inducing
p53 , inhibitors of transcription did not
induce HIF-1alpha
Larsen et al., Adv Exp Med Biol 2005
(Neoplasms) :
Moreover,
p53 is
stabilized by binding to
HIF-1alpha , whereas its interaction with Jab1 targets p53 for degradation
Calvert et al., J Appl Physiol 2006
(Brain Ischemia...) :
An increase in the dephosphorylated form of
HIF-1alpha was
followed by an increase in the association of HIF-1alpha with p53 and an increase in
p53 levels
Achison et al., Oncogene 2007
(Neoplasms) :
p53 is not
required , however, for the rimcazole induced engagement of
HIF-1alpha in proapoptotic mode as HIF-1alpha knockdown attenuates rimcazole induced death to comparable extents in p53 mutant and wild-type cell systems
Koh et al., Mol Cancer Ther 2008
:
Studies of the mechanism of PX-478 action showed that
HIF-1alpha inhibition occurs in both normoxia and hypoxia and does not
require pVHL or
p53
Bove et al., J Biol Chem 2008
(Inflammation) :
Finally, NO-mediated inhibition of cell migration was associated with
HIF-1alpha dependent induction of PAI-1 and activation of
p53 , both negative regulators of epithelial cell migration
Yang et al., Mol Cell Biol 2009
:
Here, we show that induction of
p53 by the small-molecule RITA ( reactivation of p53 and induction of tumor cell apoptosis ) [ 2,5-bis ( 5-hydroxymethyl-2-thienyl ) furan ] ( NSC-652287 )
inhibits HIF-1alpha and vascular endothelial growth factor expression in vivo and induces significant tumor cell apoptosis in normoxia and hypoxia in p53 positive cells
Choy et al., J Cell Physiol 2010
(Cardiomegaly...) :
PKB/Akt activation inhibits
p53 mediated
HIF1A degradation that is independent of MDM2 ... In that context,
p53 induces
HIF1A degradation which in turn provokes the transition from compensatory hypertrophy to myocardial thinning and chamber dilatation ( Sano et al., 2007, Nature 446 : 444-448 ) ... In order to investigate the mechanism of
p53 induced
HIF1A degradation, we used the established in vitro model of deferroxamine ( DFX ) -induced HIF1A accumulation in H9c2 cardiac cells ( Sano et al., 2007, Nature 446 : 444-448 ) ... In summary, we propose that
p53 induced
HIF1A degradation is not exclusively MDM2 mediated, but reversible by PKB/Akt phosphorylation
Lou et al., PloS one 2010
:
Camptothecin is a reported inhibitor of HIF-1alpha translation, while mitomycin C has been reported to induce
p53 dependent
HIF-1alpha degradation ... In this study we demonstrate that the inhibitory effect of mitomycin C on
HIF-1alpha protein expression is not
dependent on
p53 and protein degradation, but also involves HIF-1alpha translational regulation
Rohwer et al., PloS one 2010
(Stomach Neoplasms) :
HIF-1alpha markedly
suppressed chemotherapy induced activation of
p53 and p21 as well as the retinoblastoma protein, eventually resulting in cell cycle arrest ... Reduced formation of reactive oxygen species in HIF-1alpha-competent cells was identified as the molecular mechanism of
HIF-1alpha mediated inhibition of
p53 ... Furthermore, loss of
HIF-1alpha abrogated, in a
p53 dependent manner, chemotherapy induced DNA binding of NF-kappaB and expression of anti-apoptotic NF-kappaB target genes