Gene interactions and pathways from curated databases and text-mining

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HINT1 — TCF4

Text-mined interactions from Literome

Weiske et al., J Cell Sci 2005 : In this context, Hint1/PKCI acts as a negative regulator of TCF-beta-catenin transcriptional activity in Wnt transfected cells and in SW480 colon carcinoma cells as shown in reporter gene assays
Wang et al., Cancer Res 2007 (Colonic Neoplasms) : Because of the important role of the activator protein-1 (AP-1) transcription factor in cancer cells, we examined possible effects of HINT1 on AP-1 transcription factor activity in SW480 cells transfected with an AP-1-luciferase reporter
Wang et al., Int J Cancer 2009 (Carcinoma, Hepatocellular...) : HINT1 inhibits beta-catenin/TCF4 , USF2 and NFkappaB activity in human hepatoma cells ... HINT1 also inhibited NFkappaB transcription factor reporter activity and inhibited translocation of the endogenous p65 protein to the nucleus of HepG2 cells