Gene interactions and pathways from curated databases and text-mining

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HRAS — RALA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Gotoh et al., J Biol Chem 2000 (Breast Neoplasms) : In contrast to several other Ral-GEFs, the Ral GEF activity of AND-34 is not augmented by constitutively active Ha-Ras ( Val-12 ), consistent with the absence of a detectable Ras binding domain
Okan et al., Oncogene 2001 : Here we show that uPAR transcription is stimulated by V12 H-Ras , the effector loop mutant V12 H-Ras G37 and constitutively-active RalA 72L. RalA dependent transcription required the presence of the ATF2-like AP1-site at -70 bp and the c-Jun binding motif at -184 bp in the uPAR promoter
Xu et al., Mol Cell Biol 2003 : These data suggest a model whereby H-Ras stimulates the activation of both RalA and ARF6, which together lead to the elevation of PLD activity