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AVP — HSPG2
Text-mined interactions from Literome
Chardonnens et al., J Biol Chem 1990
:
Under those conditions, AVP induced PGI2 production did not correlate either with PMA induced membranous PKC activity or with
AVP induced
PLC activation ... Thus, the possibility is raised that, while inhibiting
AVP induced
PLC activation, PMA induced PKC activation increases the Ca2+ sensitivity of the cellular signaling system leading to PGI2 production
Teitelbaum et al., Am J Physiol 1990
:
Conversely, inhibition of AC by 2',5'-dideoxyadenosine ( DDA ) unmasks
PLC activity in
response to 10 ( -7 ) M
AVP that is not observed in the absence of DDA ... These findings demonstrate the reciprocal relationship between
AVP stimulated AC and
PLC activities in cultured RIMCT cells, which may explain previous divergent results regarding the ability of AVP to stimulate PLC in this tissue
Taylor et al., Biochem J 1987
:
[
8-arginine]Vasopressin ( 100 nM )
stimulated the
PLC activity approx. 2-fold in the presence of 10 nM-GTP [ S ], but had no effect in the absence of GTP [ S ] or at 1 microM-GTP [ S ]
Xuan et al., Biochem Biophys Res Commun 1987
:
Protein kinase C activator, phorbol ester blocks the AVP effect on the production of inositol phosphates, suggesting that
AVP induced
phospholipase C (PLC) activation is under the negative feedback regulation by diacylglycerol production ... This result suggests that a novel G-protein similar to transducin might be involved in the
AVP induced
PLC activation
Chen et al., J Pharmacol Exp Ther 1994
(Insulinoma) :
These results suggested : 1 ) U-73122 blocks
PLC activities but fails to block other signal transduction pathways that trigger insulin secretion in these cells and 2 )
AVP increases insulin release from RINm5F cells through both the PLC mediated Ca ( ++ ) -dependent and Ca ( ++ ) -independent pathways
Teitelbaum et al., Am J Physiol 1994
:
Rather, when cytosolic Ca2+ is increased,
AVP stimulates
PLC ; the ensuring activation of PKC inhibits cAMP formation
Wayte et al., Neuroreport 1997
:
PC-PLC ( 0.05-01 U ml-1 )
increased ir-AVP release but PI-PLC ( 0.01-0.5 U ml-1 ) did not
Côté et al., Endocr Res 1998
:
According to classic studies, Ang II and
AVP activate
phospholipase C (PLC) , diacylglycerol ( DAG ) and inositol phosphate ( InsPs ) production whereas ACTH activates cAMP production