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IBD4 — IL21

Text-mined interactions from Literome

Liu et al., Inflamm Bowel Dis 2009 (Inflammatory Bowel Diseases) : IL-21 enhances IBD NK cell cytotoxic response, triggers T cells to produce proinflammatory cytokines, and induces IBD CD4 ( + ) T cells to differentiate into Th17 cells, suggesting that IL-21 is involved in the pathogenesis of IBD and that blocking IL-21R signaling may have a therapeutic potential in IBD
Pallone et al., Expert Rev Clin Immunol 2010 (Inflammatory Bowel Diseases) : Role of IL-21 in inflammatory bowel disease
De Nitto et al., World J Gastroenterol 2010 (Crohn Disease...) : In this article, we review the available data supporting the pathogenic role of IL-21 in IBD
MacDonald et al., Biochem Soc Trans 2011 (Inflammatory Bowel Diseases) : The opposing roles of IL-21 and TGFß1 in chronic inflammatory bowel disease
Ligumsky et al., Gut 1990 (Colitis, Ulcerative...) : Role of interleukin 1 in inflammatory bowel disease -- enhanced production during active disease