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ICR1 — IGF2

Text-mined interactions from Literome

Szabó et al., Curr Biol 2000 : Parent-of-origin-specific expression of the mouse insulin-like growth factor 2 (Igf2) gene and the closely linked H19 gene are regulated by an intervening 2 kb imprinting control region ( ICR ) , which displays parentspecific differential DNA methylation [ 1 ] [ 2 ]
Banerjee et al., TheScientificWorldJournal 2001 : On paternal inheritance, the methylated ICR silences the H19 gene and indirectly facilitates transcription from the distant Igf2 promoter, whereas on the maternal chromosome the unmethylated ICR , together with enhancers, activates transcription of the H19 gene and thereby contributes to the repression of Igf2
Szabó et al., Mol Cell Biol 2004 : A approximately 2.4-kb imprinting control region ( ICR ) regulates somatic monoallelic expression of the Igf2 and H19 genes ... In somatic cells, the hypomethylated maternally inherited ICR binds the insulator protein CTCF at four sites and blocks activity of the proximal Igf2 promoter by insulating it from its distal enhancers
Szabó et al., Mol Cell Biol 2004 : Parent-of-origin-specific expression of the mouse insulin-like growth factor 2 gene (Igf2) and the closely linked H19 gene located on distal chromosome 7 is regulated by a 2.4-kb imprinting control region ( ICR ) located upstream of the H19 gene
Katz et al., Mol Cell Biol 2005 : The imprinted expression of the H19 and Igf2 genes in the mouse is controlled by an imprinting control center ( ICR ) whose activity is regulated by parent-of-origin differences in methylation
Szabó et al., Cytogenet Genome Res 2006 : The hypomethylated maternally inherited ICR binds the insulator protein CTCF at four sites, and blocks activity of the proximal Igf2 promoter by insulating it from the shared distal enhancers
Kurukuti et al., Proc Natl Acad Sci U S A 2006 : CTCF binding in the maternal ICR regulates its interaction with matrix attachment region ( MAR ) 3 and DMR1 at Igf2 , thus forming a tight loop around the maternal Igf2 locus, which may contribute to its silencing
Han et al., Mol Cell Biol 2008 : A paternally methylated imprinting control region ( ICR ) directs allele-specific expression of the imprinted H19 and Igf2 genes
Demars et al., Hum Mol Genet 2010 (Beckwith-Wiedemann Syndrome...) : The imprinted expression of the IGF2 and H19 genes is controlled by the imprinting control region 1 (ICR1) located at chromosome 11p15.5
Ideraabdullah et al., Dev Biol 2011 : Like most imprinted genes, H19 and Igf2 are regulated by a differentially methylated imprinting control region ( ICR )
Raef et al., Clin Endocrinol (Oxf) 2011 (Adenoma, Islet Cell...) : ICR1 and ICR2 control the expression of IGF-2 and CDKN1C/p57KIP2, respectively
Poole et al., Eur J Hum Genet 2012 (Beckwith-Wiedemann Syndrome) : The imprinted expression of the IGF2 and H19 genes is controlled by the imprinting control region 1 (ICR1) located at chromosome 11p15.5