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IFNA5 — JAK1

Pathways - manually collected, often from reviews:

• Reactome Reaction: IFNA5 → JAK1 (indirect_complex) You et al., Mol Cell Biol 1999, Chuntharapai et al., J Immunol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Chill et al., Structure 2003, Lamken et al., J Mol Biol 2004, Gavutis et al., Biophys J 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Li et al., Mol Cell Biol 1997, Domanski et al., J Biol Chem 1997
• Reactome Reaction: IFNA5 → JAK1 (reaction) Chuntharapai et al., J Immunol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Chill et al., Structure 2003, Lamken et al., J Mol Biol 2004, Gavutis et al., Biophys J 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Gauzzi et al., J Biol Chem 1996, Li et al., Mol Cell Biol 1997, Domanski et al., J Biol Chem 1997

Text-mined interactions from Literome

Li et al., Oncogene 1999 : The human papilloma virus ( HPV ) -18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha
Joo et al., Arch Pharm Res 2006 : In our study, we were able to determine that DDB stimulates Jak/Stat signaling, and induces the expression of interferon alpha ( IFN-alpha ) stimulated genes, most notably 6-16 and ISG12
Wang et al., Nat Immunol 2008 : CaMK and Pyk2 relayed signals from integrins and the ITAM containing adaptor DAP12 to augment interleukin 10- and interferon-alpha induced Jak activation and STAT1 dependent gene expression
Platanias et al., J Biol Chem 1996 : Binding of interferon alpha ( IFN alpha ) to its receptor induces activation of the Tyk-2 and Jak-1 tyrosine kinases and tyrosine phosphorylation of multiple downstream signaling elements, including the Stat components of the interferon stimulated gene factor 3 ( ISGF-3 )
Novak et al., Growth Factors 1996 : Instead of increased phosphorylation of JAK1 and JAK2 in response to G-CSF and interferon-gamma, and JAK1 and Tyk2 in response to interferon-alpha/beta , we observed only an increase of phosphorylation of Tyk2 in response to all of these cytokines in NFS-60 cells
Krishnan et al., Eur J Biochem 1997 : Kinase-deficient forms of Jak1 and Tyk2 inhibit interferon alpha signaling in a dominant manner