Gene interactions and pathways from curated databases and text-mining

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CXCL12 — IFNG

Text-mined interactions from Literome

Nanki et al., J Immunol 2000 : In addition, SDF-1alpha costimulated proliferation of CD4+ T cells and production of IL-2, IFN-gamma , IL-4, and IL-10
Hardaker et al., FASEB J 2004 (Inflammation...) : In primary cultured hASM cells taken from normal donors, CXCL10 protein expression was induced by IFN-gamma and TNF-alpha, cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Poggi et al., Blood 2004 (HIV Infections) : gamma delta T cells transmigrated across endothelial monolayers, in response to interferon-gamma inducing protein-10 ( IP-10/CXCL10 ), stromal cell derived factor-1 ( SDF-1/CXCL12 ), or both, according to the expression of the specific receptors CXCR3 and CXCR4
Hillyer et al., Clin Exp Immunol 2003 : In combination with TNF-alpha, IFN-gamma suppressed CXCL8 but enhanced CCL5 and CXCL10, whereas transforming growth factor ( TGF ) -beta reduced secretion of all chemokines
Salvucci et al., J Leukoc Biol 2004 (Neovascularization, Pathologic) : In vivo, TNF-alpha and IFN-gamma inhibit growth factor induced angiogenesis and SDF-1 expression in endothelial cells
Han et al., J Leukoc Biol 2004 (Arteriosclerosis) : lysoPC also enhanced SDF-1 stimulated production of inflammatory cytokines interleukin-2 and interferon-gamma by CD4 T cells activated by anti-CD3 immunoglobulin G
Thomas et al., J Immunol 2004 (Bronchial Hyperreactivity) : In lymphocytes restimulated with CXCL9 and allergen in vitro, CXCL9 down-regulated IL-4 expression and up-regulated IFN-gamma expression, suggesting that CXCL9 is able to direct activated lymphocytes toward a Th1-type phenotype
Traidl-Hoffmann et al., Int Arch Allergy Immunol 2006 : Keratinocyte cultures established from normal skin of healthy donors were activated by IFN-gamma in the absence or presence of desloratadine and loratadine, and tested for the release of CCL5/RANTES, CXCL8/IL-8 , CCL17/TARC and CXCL10/IP-10 ... Desloratadine and loratadine inhibited the constitutive and IFN-gamma induced release of CCL5, CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged
Bandyopadhyay et al., Biochem Pharmacol 2006 : In addition, apigenin inhibits IFNgamma stimulated secretion of monokines, CXCL-9 , and -10 in MC3T3-E1 cells
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin enhances interferon-gamma induced production of CXC ligand 9 (CXCL9), CXCL10 , and CXCL11 in human keratinocytes ... Although prolactin alone was ineffective, it enhanced IFN-gamma induced secretion and mRNA expression of CXCL9, CXCL10 , and CXCL11 in parallel to the activation of STAT1, NF-kappaB, and IRF-1 ... These results suggest that prolactin may enhance IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in keratinocytes via activation of STAT1, NF-kappaB, and IRF-1 through JAK2 and MEK/ERK pathways
Kanda et al., Eur J Immunol 2007 : IL-18 enhances IFN-gamma induced production of CXCL9, CXCL10 , and CXCL11 in human keratinocytes ... We examined the in vitro effects of IL-18 on IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in human keratinocytes ... IL-18 enhanced the IFN-gamma induced secretion and mRNA expression of CXCL9, CXCL10 , and CXCL11 in parallel to the activation of NF-kappaB, STAT1, and IFN-regulatory factor (IRF)-1 ... These results suggest that IL-18 may potentiate IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in keratinocytes by activating NF-kappaB, STAT1, or IRF-1 through PI3 K/Akt and MEK/ERK pathways
Taubert et al., Vet Res Commun 2008 : Furthermore, IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin, CXCL1, CXCL8 , CCL5, COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription
Irhimeh et al., Exp Hematol 2007 (Neoplasms) : The proportion of CD34 ( + ) cells that expressed CXCR4 increased from 45 to 90 % after 12 days, the plasma level of SDF-1 increased from 1978 to 2010 pg/mL, and IFN-gamma level increased from 9.04 to 9.89 pg/mL
Milks et al., Liver Int 2009 (Disease Models, Animal...) : Ifng is dichotomous in the regulation of distinct chemokine subfamilies : specifically, Ifng is critical for overexpression of specific CXCL genes but dispensable for overexpression of specific CCL genes
Nikolinakos et al., Cancer Res 2010 (Carcinoma, Non-Small-Cell Lung...) : Increases were also observed in stromal cell derived factor-1alpha , IP-10, cutaneous T-cell attracting chemokine, monokine induced by IFN-gamma , tumor necrosis factor related apoptosis inducing ligand, and IFN-alpha