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IGF2 — PTEN
Text-mined interactions from Literome
Tanno et al., Cancer Res 2001
(Neoplasm Invasiveness...) :
Furthermore, AKT induced
IGF-IR expression was
down-regulated by dominant negative Src or
PTEN
Kang-Park et al., FEBS Lett 2003
(Carcinoma, Hepatocellular...) :
In this report we demonstrate that the
PTEN effect on HBx
induced IGF-II activation in a hepatoma cell line
Moorehead et al., J Biol Chem 2003
:
Insulin-like growth factor-II regulates
PTEN expression in the mammary gland ... Here we show that
insulin-like growth factor-II (IGF-II) , which signals through PI3K,
regulates PTEN expression in the mammary gland ... Transgenic
IGF-II expression also
increased mammary
PTEN protein, leading to reductions in Akt phosphorylation, epithelial proliferation, and mammary morphogenesis ...
IGF-II induced
PTEN promoter activity and protein levels and this involved the immediate early gene egr-1 ... Thus, we have identified a novel negative feedback loop within the PI3K pathway where
IGF-II induces
PTEN expression to modulate its physiologic effects
Zhao et al., Oncogene 2004
(Prostatic Neoplasms) :
Interestingly,
PTEN overexpression
resulted in a 44-60 % reduction in total insulin-like growth factor-I receptor (
IGF-IR ) protein levels and a 49-64 % reduction in cell surface IGF-IR expression ... [ 35S ] methionine pulse experiments in PC3 cells overexpressing PTEN demonstrated that these cells synthesize significantly lower levels of the IGF-IR precursor, whereas
PTEN overexpression
had no effect on
IGF-IR degradation
Yi et al., Biochem Biophys Res Commun 2005
(Adenocarcinoma...) :
PTEN overexpression
resulted in a significant decrease in the expression of IGF-I, -II, and
IGF-IR
Al-Khouri et al., J Biol Chem 2005
:
Finally,
PTEN phosphorylation was
affected by
insulin-like growth factor in intact cells
Hwang et al., Exp Mol Med 2005
(Stomach Neoplasms) :
PTEN overexpression
induced a profound decrease in the IGF-II and
IGF-IR expression levels, and downregulation of IGF-II expression by PTEN was mediated through the regulation of the IGF-II promoter
Perks et al., Oncogene 2007
(Breast Neoplasms...) :
IGF-II and IGFBP-2 differentially
regulate PTEN in human breast cancer cells ...
PTEN expression is
stimulated by
IGF-II forming a feedback loop
Jones et al., Lancet Oncol 2009
(Breast Neoplasms) :
Potential mechanisms of resistance to trastuzumab include bypass mechanisms, mutations of the HER2 target, masking of HER2 proteins,
inhibition of
insulin-like growth factor , and
phosphatase and tensin homologue (PTEN) deficiency