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IGFBP4 — PTH
Text-mined interactions from Literome
Rosen et al., J Clin Endocrinol Metab 1992
(Hip Fractures...) :
Based on previous work, we speculate that production of the 24/25-kDa
IGFBP , which in vitro is known to inhibit IGF-I- and IGF-II mediated osteoblast function, may be
stimulated by
PTH in patients with the syndrome of age related osteoporosis
Hassager et al., J Clin Endocrinol Metab 1992
:
PTH increased a 29-kDa
IGFBP apparent only in UMR 106-01 cell conditioned medium, whereas GH had no direct effect on IGFBP secretion in any of the osteoblast-like cells tested
Tørring et al., Endocrinology 1991
:
Agents that elevate intracellular cAMP by different mechanisms [ ( Bu ) 2cAMP, forskolin, and isobutylmethylxanthine ] mimicked the
effect of
PTH and PTHrP on
IGFBP synthesis ... In comparison,
PTH did not
stimulate IGFBP production in fibroblasts and ROS 17/2.8 cells, which secrete IGFBPs of 42,000, 38,000, 34,000, 28,000, and 24,000 Mr, but not of 29,000 Mr. The PTH-responsive IGFBPs from UMR cells were nonglycosylated proteins with preferential affinity for IGF-I over IGF-II
Kudo et al., Biochim Biophys Acta 1995
(Osteoporosis, Postmenopausal) :
We have therefore studied the
effects of 17 beta-estradiol and
parathyroid hormone (PTH) on binding activity of
IGFBP-4 and osteoblastic activity using SaOS-2 osteoblastic cells ... The binding activity of IGFBP-4 was stimulated 2-fold by 10 nM PTH, while this
PTH induced
IGFBP-4 production was completely inhibited by the addition of 17 beta-estradiol
Kudo et al., Life Sci 1997
:
Together with our previous report that 17beta-estradiol inhibits the
PTH induced reduction of
IGFBP-4 proteolysis in these cells, the results obtained may help to explain the mechanisms of determining IGFBP-4 availability by systemic hormones in osteoblast cells