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IKBKG — RAC1

Text-mined interactions from Literome

Venkatesan et al., J Mol Cell Cardiol 2010 : EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1 dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling ... We show for the first time that EMMPRIN stimulates the activation of NF-kappaB, AP-1, CREB, and ATF-2 in cardiomyocytes, and induces IL-18 expression via Rac1 dependent PI3K/Akt/IKK/NF-kappaB and MKK7/JNK/AP-1 signaling
Valente et al., Free Radic Biol Med 2013 : Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide dependent TRAF3IP2/JNK signaling ... AOPP-MSA stimulated Nox2/Rac1 dependent superoxide generation, TRAF3IP2 expression, and TRAF3IP2 dependent JNK activation ... These results demonstrate for the first time that AOPPs induce cardiomyocyte death via Nox2/Rac1/superoxide dependent TRAF3IP2/JNK activation in vitro and suggest that AOPPs may contribute to myocardial injury in vivo